J Allergy Clin Immunol:慢性鼻窦炎急性发作的相关临床因素研究

2020-02-08 AlexYang MedSci原创

慢性鼻窦炎(CRS)经常并发急性加重情况,导致了明显医疗负担并损害了生活质量。最近,有研究人员鉴定了与慢性鼻窦炎极性发作(AECRS)相关的临床因素。研究是一个回顾性的CRS患者群体研究,时间为2014年1月1日到2016年5月31日。经常性AECRS定义为12个月期间发作不少于4次,0-3次定义为不常发作的AECRS。研究人员共鉴定了3109名患者,600(19.3%)名分类为经常发作的患者。研

慢性鼻窦炎(CRS)经常并发急性加重情况,导致了明显医疗负担并损害了生活质量。最近,有研究人员鉴定了与慢性鼻窦炎极性发作(AECRS)相关的临床因素。

研究是一个回顾性的CRS患者群体研究,时间为2014年1月1日到2016年5月31日。经常性AECRS定义为12个月期间发作不少于4次,0-3次定义为不常发作的AECRS。研究人员共鉴定了3109名患者,600(19.3%)名分类为经常发作的患者。研究发现,哮喘、过敏性鼻炎、嗜酸性细胞数目≥150/μL和自身免疫疾病均与经常性AECRS相关,且在多变量分析中调整了年龄、种族和性别后的调整后风险比(aOR)具有统计学显著性(哮喘aOR 2.61, 95% CI 2.14-3.18, 过敏性鼻炎aOR 1.96, 95% CI 1.58-2.42, 嗜酸性细胞数≥150/μL aOR 1.54, 95% CI 1.21-1.97和自身免疫疾病 aOR 1.68, 95% CI 1.36-2.07)。另外,抗体缺陷、抗生素过敏、更低的FEV1、鼻窦疾病的严重程度、鼻息肉和全身性皮质类固醇的使用均与经常性AECRS相关。

最后,研究人员指出,常发作的AECRS患者具有更高的哮喘、过敏性鼻炎、嗜酸性细胞数≥150/μL、自身免疫疾病和其他过敏和免疫疾病患病率特征。他们的发现鉴定了CRS高风险患者亚型,从而促进预防干预来减少发作频率。

原始出处:

Kwah JH, Somani SN, Stevens WW et al. Clinical Factors Associated with Acute Exacerbations of Chronic Rhinosinusitis. J Allergy Clin Immunol. 28 Jan 2020.

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    2020-07-29 howi
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    2020-02-10 膀胱癌
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