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Int J Stroke：拯救半暗带，怎么利用溶栓时间窗的黄金时间呢？

2017-08-11 shaosai MedSci原创

急性脑卒中半暗带静脉溶栓
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科学的多模态影像学检查，包括CTA和CTP，能够提过颅内血管和颅脑灌注情况并能够区分梗死核心和半暗带，从而对静脉溶栓患者的选择提供了可靠科学的信息。本研究提出假说：多模态影像学技术能够增加静脉溶栓的数量并改善治疗预后，并将实验结果发表在Int J Stroke上。

科学的多模态影像学检查，包括CTA和CTP，能够提过颅内血管和颅脑灌注情况并能够区分梗死核心和半暗带，从而对静脉溶栓患者的选择提供了可靠科学的信息。本研究提出假说：多模态影像学技术能够增加静脉溶栓的数量并改善治疗预后，并将实验结果发表在Int J Stroke上。PRACTISE是一项前瞻性多中心随机对照试验，本研究共纳入了400例发病4.5小时内的急性脑卒中患者，随机划为CT平扫组和多模态组（CT平扫+CTA+CTP）。记录各患者使用组织型纤溶酶原激活物进行静脉溶栓的临床决策，以及各组检查时间和从入院到开始静脉溶栓治疗的时间。24小时对患者进行颅脑检查并测量梗死体积、水肿和脑出血情况。在基线、24小时和7±2天对患者进行NIHSS和90进行mRS来评估预后。本研究主要结果是患者接受静脉溶栓的比例；另外，评价了临床决策时间、对不同影像学图像处理软件之间进行比较以及3个月后临床预后。本研究表明，多模态CT检查是对于急性脑卒中患者进行血管再通治疗决策非常有用的工具。但对于增加检查手段是否对所有脑卒中患者的有益性尚不明确。原始出处：El-Tawil S， Wardlaw J， Ford I，

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  1. 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createdTime=Sat Aug 19 19:13:32 CST 2017, time=2017-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233497, encodeId=cf8c23349eb9, content=半暗带，再次学习了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/C3426ED027FF661B0C576A5B3127C2E8/40, createdBy=39dc1706090, createdName=QQ25ed180f, createdTime=Mon Aug 14 15:00:36 CST 2017, time=2017-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233384, encodeId=31bc233384f8, content=认真学习，把间接经验应用到临床实践中去，然后再总结出新思路。给点赞啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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content=发达国家的精准医学路, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCclExeQ6LOGMD4dTsia4Ty4HtZCxRmG5vO5XIKfKX3a3vusfhHSej4Iib517vmhFW7RQgh7bpDp1yw/0, createdBy=50951609779, createdName=baihao215, createdTime=Sat Aug 12 07:08:27 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232558, encodeId=418623255869, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Fri Aug 11 20:36:56 CST 2017, time=2017-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232496, encodeId=00d823249615, content=学习学习再学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20231215/ac08b4d4cecf4bd3b9af86e00dcbca38/f6b6a60efd854ff191eb5c611ec7dd12.jpg, createdBy=8afb2071832, createdName=15938038573红旗飘飘, createdTime=Fri Aug 11 16:50:20 CST 2017, time=2017-08-11, status=1, ipAttribution=)]
    2017-08-30 虈亣靌

    不错的.学习了.谢谢分享!

    0

  2. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232496, encodeId=00d823249615, content=学习学习再学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20231215/ac08b4d4cecf4bd3b9af86e00dcbca38/f6b6a60efd854ff191eb5c611ec7dd12.jpg, createdBy=8afb2071832, createdName=15938038573红旗飘飘, createdTime=Fri Aug 11 16:50:20 CST 2017, time=2017-08-11, status=1, ipAttribution=)]
    2017-08-19 虈亣靌

    讲解的非常好,值得学习

    0

  3. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232496, encodeId=00d823249615, content=学习学习再学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20231215/ac08b4d4cecf4bd3b9af86e00dcbca38/f6b6a60efd854ff191eb5c611ec7dd12.jpg, createdBy=8afb2071832, createdName=15938038573红旗飘飘, createdTime=Fri Aug 11 16:50:20 CST 2017, time=2017-08-11, status=1, ipAttribution=)]
    2017-08-14 QQ25ed180f

    半暗带，再次学习了！

    0

  4. 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    2017-08-14 ylzr123

    认真学习，把间接经验应用到临床实践中去，然后再总结出新思路。给点赞啦

    0

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    2017-08-13 12498cbcm05(暂无昵称)

    #半暗带#

    0

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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232496, encodeId=00d823249615, content=学习学习再学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20231215/ac08b4d4cecf4bd3b9af86e00dcbca38/f6b6a60efd854ff191eb5c611ec7dd12.jpg, createdBy=8afb2071832, createdName=15938038573红旗飘飘, createdTime=Fri Aug 11 16:50:20 CST 2017, time=2017-08-11, status=1, ipAttribution=)]
    2017-08-12 虈亣靌

    不错的，学习了！谢谢分享！

    0

  7. 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    2017-08-12 执着追梦

    学习，谢谢分享

    0

  8. 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    2017-08-12 baihao215

    发达国家的精准医学路

    0

  9. 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    2017-08-11 清风拂面

    谢谢分享，学习了

    0

  10. 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    2017-08-11 15938038573红旗飘飘

    学习学习再学习

    0

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