Eur Heart J:房颤患者口服抗凝药可减少痴呆!

2017-10-25 xing.T MedSci原创

由此可见,没有接受口服抗凝治疗的房颤患者发生痴呆的风险更高。这表明房颤患者早期开始抗凝治疗在保持认知功能上很有价值。

房颤动与痴呆之间的关系已经被很好地证实,但是口服抗凝治疗是否会提供保护性效应尚不清楚。近日,心血管领域权威杂志Eur Heart J上发表了一篇研究文章,研究人员的目的是比较有无口服抗凝药物治疗的房颤患者新发痴呆的发病率,并探讨新型抗凝药和华法林在这方面是否有区别。

研究人员将2006年至2014年期间瑞典所有住院诊断为房颤但是之前无痴呆诊断的患者纳入进行回顾性登记研究。研究人员根据意向治疗和治疗原则采用倾向评分匹配进行分析。

这项研究共纳入了444106例房颤患者。研究人员发现在基线时,相比于没有进行抗凝治疗的患者,接受抗凝治疗的患者患痴呆的风险降低了29%(风险比为0.71,95%可信区间为0.68-0.74),在治疗过程中风险降低了48%(风险比为0.52,95%可信区间为0.50-055)。直接比较了新型口服抗凝剂和华法林并没有差别(风险比为0.97,95%可信区间为0.67-1.40)。

由此可见,没有接受口服抗凝治疗的房颤患者发生痴呆的风险更高。这表明房颤患者早期开始抗凝治疗在保持认知功能上很有价值。

原始出处:

Leif Friberg,et al. Less dementia with oral anticoagulation in atrial fibrillation. Eur Heart J. 2017.https://doi.org/10.1093/eurheartj/ehx579

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    2017-11-02 微分

    学习了新知识

    0

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    2017-10-31 sunfeifeiyang

    房颤抗凝少痴呆.是因为疏通血管的事?

    0

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    2017-10-27 zhaojie88
  4. 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  5. 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createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Thu Oct 26 05:35:12 CST 2017, time=2017-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255987, encodeId=8e1e25598e7b, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo4cyIbibqa2VuNGCKeyRxITYNqLTIaoFo3Jx2LSawp8yrFSs1CIXKv1jyXV97ecnxhhktGKkPP9onfJFZCbiayLgic/0, createdBy=3f1c1956638, createdName=1e127dd4m40(暂无匿称), createdTime=Thu Oct 26 00:29:15 CST 2017, time=2017-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255982, encodeId=04312559828a, content=不错的.学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Thu Oct 26 00:25:01 CST 2017, time=2017-10-26, status=1, ipAttribution=)]
    2017-10-27 slcumt
  6. 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  7. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Thu Oct 26 00:25:01 CST 2017, time=2017-10-26, status=1, ipAttribution=)]
    2017-10-26 明月清辉

    谢谢分享.学习了

    0

  8. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Thu Oct 26 00:25:01 CST 2017, time=2017-10-26, status=1, ipAttribution=)]
    2017-10-26 yjs木玉

    好好好好好好好

    0

  9. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Thu Oct 26 00:25:01 CST 2017, time=2017-10-26, status=1, ipAttribution=)]
    2017-10-26 1e127dd4m40(暂无匿称)

    学习了

    0

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    2017-10-26 中医痴

    不错的.学习了.谢谢分享!

    0

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据美国心脏协会(AHA)估计,美国心房颤动(AF)患者数量约为270万~600万,预计2030年将增至3000万。AF若不治疗可增加心脏相关死亡及卒中风险,因此,了解其可改变的危险因素并预防将有助于显着降低AF的发病。近期,Circulation上发表的一项最新大型研究表明,与女性相比,男性AF的发病要早约十年,而超重则是其主要的危险因素。

NEJM:PCI后房颤患者接受达比加群二联预防方案的效果研究

研究认为,对于接受经皮冠状动脉介入治疗的房颤患者接受达比加群联合 P2Y12抑制剂的二联治疗其出血风险低于经典的华法林、P2Y12抑制剂与阿司匹林三联疗法。二联疗法对于血栓事件的预防效果非劣于三联疗法