Clin Neurophysiol:异丙酚与七氟醚对小儿麻醉诱导期癫痫样放电发生率的比较

2018-08-12 李华宇 罂粟花

在儿科患者中,常用于麻醉诱导。虽然癫痫样放电可发生在七氟醚诱麻醉导期间,但异丙酚麻醉诱导期间其发生率尚未有文献报道。本研究的目的是比较异丙酚与七氟醚麻醉诱导期间儿童癫痫样放电的发生率。

背景与目的

在儿科患者中,常用于麻醉诱导。虽然癫痫样放电可发生在七氟醚诱麻醉导期间,但异丙酚麻醉诱导期间其发生率尚未有文献报道。本研究的目的是比较异丙酚与七氟醚麻醉诱导期间儿童癫痫样放电的发生率。

方  法

对0.5-8岁拟行择期手术的儿童进行前瞻性观察性队列研究。并对其采用异丙酚或七氟醚用于麻醉诱导。在麻醉开始前放置双额脑电图电极。从施用麻醉药物开始直至插管期间进行视觉脑电图分析,以鉴别癫痫样模式,即具有刺突的δ; 节奏性聚糖蛋白; 周期性,癫痫样放电; 或抑制尖峰。

结  果

39名儿童用异丙酚麻醉,18名儿童用七氟醚麻醉。异丙酚组中有36%的儿童出现癫痫样放电,而七氟醚组为67%(p = 0.03)。不同类型的癫痫样放电其发生率不同,如周期性癫痫样放电(七氟醚组39%与异丙酚组3%; p <0.001)。高浓度瑞芬太尼(0.15 mg / kg / min)与低频率癫痫样放电相关(实验5.8; CI 95%1.6 / 21.2; p = 0.008)。

结  论

异丙酚用于小儿麻醉诱导会引起癫痫样放电,但其发生率低于七氟醚。

原始出处:

Koch S, Rupp L, Prager C,et al. Incidence of epileptiform discharges in children during induction of anaesthesia using Propofol versus Sevoflurane. Clin Neurophysiol. 2018 Jun 8;129(8):1642-1648. doi: 10.1016/j.clinph.2018.05.013.

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    2018-08-15 苏小雨

    学习了

    0

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    2018-08-14 lq0303
  7. [GetPortalCommentsPageByObjectIdResponse(id=1705571, encodeId=16551e055715d, content=<a href='/topic/show?id=8c77103094c3' target=_blank style='color:#2F92EE;'>#麻醉诱导期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103094, encryptionId=8c77103094c3, topicName=麻醉诱导期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc9630990780, createdName=mxj1971622, createdTime=Wed Oct 31 10:51:00 CST 2018, time=2018-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1826467, encodeId=ed0b182646ed5, content=<a href='/topic/show?id=e5283e89970' target=_blank style='color:#2F92EE;'>#发生率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37899, encryptionId=e5283e89970, topicName=发生率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sat Jan 05 07:51:00 CST 2019, time=2019-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1788863, encodeId=efb61e888630c, content=<a href='/topic/show?id=866d1421e4c' target=_blank style='color:#2F92EE;'>#Physio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14217, encryptionId=866d1421e4c, topicName=Physio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sun Aug 19 22:51:00 CST 2018, time=2018-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=338810, encodeId=94c133881066, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/05/22/c26524b0b4ca80000d38f0294262c002.jpg, createdBy=3cf52015303, createdName=苏小雨, createdTime=Wed Aug 15 20:42:17 CST 2018, time=2018-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1412689, encodeId=f8f1141268984, content=<a href='/topic/show?id=1c2f195092d' target=_blank style='color:#2F92EE;'>#七氟醚#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19509, encryptionId=1c2f195092d, topicName=七氟醚)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0a102881238, createdName=linagood, createdTime=Tue Aug 14 03:51:00 CST 2018, time=2018-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468843, encodeId=76a41468843cb, content=<a href='/topic/show?id=5e0b49e1106' target=_blank style='color:#2F92EE;'>#异丙酚#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49711, encryptionId=5e0b49e1106, topicName=异丙酚)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18a56942427, createdName=lq0303, createdTime=Tue Aug 14 03:51:00 CST 2018, time=2018-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=338307, encodeId=f5b333830ed7, content=嗯嗯,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Mon Aug 13 08:59:14 CST 2018, time=2018-08-13, status=1, ipAttribution=)]
    2018-08-13 liumin1987

    嗯嗯,学习了。

    0

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