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Cytotherapy：间充质基质细胞释放的胞外囊泡可用于治疗成骨不全患者

2017-12-02 MedSci MedSci原创

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既往研究已经表明成骨不全症（OI）儿童全身输注间充质基质细胞（MSCs）可诱导骨加速生长，尽管移植骨髓中MSCs的移植量很小。我们既往研究发现OI动物输注MSC可刺激生长板中的软骨细胞增殖。本研究旨在找出介导这种治疗活性的MSCs分泌的营养因子。 为了检查MSCs释放的细胞外囊泡（EV）是否具有治疗活性，研究人员通过超速离心从MSC条件培养基分离EV。为了进一步表征营养因子，通过核糖核酸酶（RNa

既往研究已经表明成骨不全症（OI）儿童全身输注间充质基质细胞（MSCs）可诱导骨加速生长，尽管移植骨髓中MSCs的移植量很小。我们既往研究发现OI动物输注MSC可刺激生长板中的软骨细胞增殖。本研究旨在找出介导这种治疗活性的MSCs分泌的营养因子。

为了检查MSCs释放的细胞外囊泡（EV）是否具有治疗活性，研究人员通过超速离心从MSC条件培养基分离EV。为了进一步表征营养因子，通过核糖核酸酶（RNase）处理MSC或抑制miRNA生物发生去除EVs中的RNA或microRNA（miRNA）。使用体外软骨细胞增殖测定评估这些改性的EVs的功能活性。最后，在用EVs治疗的OI动物模型中评估骨生长。

结果显示，输注MSC来源的EV可刺激生长板中的软骨细胞增殖，提高OI小鼠模型中骨生长。然而，既不输注RNase处理的EVs也不消耗miRNA的EVs可增强软骨细胞增殖。

综上所述，该研究结果表明，MSCs通过分泌含有miRNA的囊泡发挥在OI中的治疗作用，EV疗法有可能成为OI的新型无细胞疗法，将克服目前MSC治疗中的一些局限性。

原始出处：

Otsuru S, Desbourdes L, et al., Extracellular vesicles released from mesenchymal stromal cells stimulate bone growth in osteogenesis imperfecta. Cytotherapy. 2017 Oct 26. pii: S1465-3249(17)30711-9. doi: 10.1016/j.jcyt.2017.09.012.

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    2018-09-10 124988c7m106暂无昵称

    #ERA#

    0

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    2018-01-01 ms7899726347904398

    #基质#

    0

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    2017-12-04 zhaojie88

    #成骨#

    0

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    2017-12-04 charl1234573

    #囊泡#

    0

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    2017-12-03 邓启付

    胞外囊泡第一次听说.学习了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1738859, encodeId=fc261e38859bb, content=<a href='/topic/show?id=6e566913df' target=_blank style='color:#2F92EE;'>#ERA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6913, encryptionId=6e566913df, topicName=ERA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e36234488643, createdName=124988c7m106暂无昵称, createdTime=Mon Sep 10 14:31:00 CST 2018, time=2018-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1757070, encodeId=dfaf1e57070d3, content=<a href='/topic/show?id=103b421e0e8' target=_blank style='color:#2F92EE;'>#基质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42170, encryptionId=103b421e0e8, topicName=基质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=281337296540, createdName=ms7899726347904398, createdTime=Mon Jan 01 01:31:00 CST 2018, time=2018-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351636, encodeId=76a5135163608, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Dec 04 06:31:00 CST 2017, time=2017-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599823, encodeId=5c88159982370, content=<a href='/topic/show?id=be324039e31' target=_blank style='color:#2F92EE;'>#囊泡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40397, encryptionId=be324039e31, topicName=囊泡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=86bc18759177, createdName=charl1234573, createdTime=Mon Dec 04 06:31:00 CST 2017, time=2017-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266379, encodeId=0cd72663e932, content=胞外囊泡第一次听说.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzcjoLTEEgkSSQ8pVIiaf4a4INaoMLBV16QEk3dvvBRpicwIwmDGv0jePErJ4aE9ibVBDPtkialQLT9Bs/0, createdBy=04811949400, createdName=邓启付, createdTime=Sun Dec 03 07:22:30 CST 2017, time=2017-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266243, encodeId=92e626624347, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sat Dec 02 20:15:38 CST 2017, time=2017-12-02, status=1, ipAttribution=)]
    2017-12-02 131****1460

    学习了受益匪浅

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