Neurology:老年慢性硬膜下血肿患者该何如使用抗凝和抗血小板治疗!

2017-04-15 xing.T MedSci原创

由此可见,抗凝药物治疗与老年慢性硬膜下血肿(cSDH)患者再出血的风险增加相关。然而,抗血小板药物治疗与再出血风险增加无关。

近日,神经病学领域权威取杂志Neurology上发表了一篇荟萃分析文章,研究人员旨在明确对慢性硬膜下血肿(cSDH)的老年患者是否要重启抗凝血剂或抗血小板药物治疗。

该研究是对以往系统评价(文献检索时间直至2012年7月)的更新。研究人员检索了MEDLINE、EMBASE、ISI Web of Knowledge、谷歌学者、PLOS和Cochrane系统评价数据库,检索时间为2012年1月至2016年12月。研究纳入的老年人(65岁以上)经历了创伤性硬膜下血肿或cSDH,并且接受了抗凝或抗血小板治疗。

该荟萃分析共纳入了7项研究(平均年龄为72岁)。7项研究中有4项研究提供了抗凝剂或抗血小板使用情况的联合数据。只有1项研究的结果表明抗凝或抗血小板药物的使用是cSDH患者发生再出血的一个重要因素。2项研究仅考虑患者使用抗凝剂,并且都报告了类似的再出血增加几率(分别有比值比为1.75,95%可信区间为0.18-16.86,比值比为2.7,95%可信区间为1.42-6.96)。研究人员没有发现抗血小板药物与再出血之间存在相关性。重新使用抗凝剂或抗血小板药物治疗的理想时机尚不清楚。

由此可见,抗凝药物治疗与老年慢性硬膜下血肿(cSDH)患者再出血的风险增加相关。然而,抗血小板药物治疗与再出血风险增加无关。

原始出处:

Santhosh Nathan,et al. Anticoagulant and antiplatelet use in seniors with chronic subdural hematoma Systematic review. Neurology. 2017. http://www.neurology.org/content/early/2017/04/14/WNL.0000000000003918.short

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    2017-10-26 yinhl1978
  4. 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  5. 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  6. 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objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJiaCBO9f33YY0a9cL4rhSH23PNEOVia2szWTbUl6IgFnukCuC2ptOD5mAC0Ax8qGt2pjwudkREHlmA/132, createdBy=d39e1630897, createdName=1dd8aa01m06(暂无匿称), createdTime=Sat Apr 15 19:24:53 CST 2017, time=2017-04-15, status=1, ipAttribution=)]
    2017-04-16 往日如昨

    学习了谢谢分享

    0

  7. 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objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJiaCBO9f33YY0a9cL4rhSH23PNEOVia2szWTbUl6IgFnukCuC2ptOD5mAC0Ax8qGt2pjwudkREHlmA/132, createdBy=d39e1630897, createdName=1dd8aa01m06(暂无匿称), createdTime=Sat Apr 15 19:24:53 CST 2017, time=2017-04-15, status=1, ipAttribution=)]
    2017-04-16 qjzhai1623

    为何要抗血小板

    0

  8. 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objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJiaCBO9f33YY0a9cL4rhSH23PNEOVia2szWTbUl6IgFnukCuC2ptOD5mAC0Ax8qGt2pjwudkREHlmA/132, createdBy=d39e1630897, createdName=1dd8aa01m06(暂无匿称), createdTime=Sat Apr 15 19:24:53 CST 2017, time=2017-04-15, status=1, ipAttribution=)]
    2017-04-15 cqykthl

    真的是吗?有更小的分层分析么?

    0

  9. 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objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJiaCBO9f33YY0a9cL4rhSH23PNEOVia2szWTbUl6IgFnukCuC2ptOD5mAC0Ax8qGt2pjwudkREHlmA/132, createdBy=d39e1630897, createdName=1dd8aa01m06(暂无匿称), createdTime=Sat Apr 15 19:24:53 CST 2017, time=2017-04-15, status=1, ipAttribution=)]
    2017-04-15 1ddf0692m34(暂无匿称)

    抗凝与预防出血

    0

  10. 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objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJiaCBO9f33YY0a9cL4rhSH23PNEOVia2szWTbUl6IgFnukCuC2ptOD5mAC0Ax8qGt2pjwudkREHlmA/132, createdBy=d39e1630897, createdName=1dd8aa01m06(暂无匿称), createdTime=Sat Apr 15 19:24:53 CST 2017, time=2017-04-15, status=1, ipAttribution=)]
    2017-04-15 1dd8aa01m06(暂无匿称)

    学习了很好的内容

    0