GUT：结直肠癌的研究空白和相关建议！

2017-12-15 MedSci MedSci原创

目前，在全球范围内，结肠直肠癌（CRC）是导致发病率/死亡率的重要原因之一。明确关键的研究差距（RG）、优先级和解决方案可以改善患者的预后。近期，一篇发表在杂志GUT上的文章对这一问题进行了剖析。RG分析由患者、临床医生和研究人员（n = 71）构成的多学科小组进行。由八个工作组（WG）组成：发现科学；风险；预防；早期诊断和筛查；病理；治愈性治疗；IV期疾病；和CRC患者一起生活。经过讨论并由一个

目前，在全球范围内，结肠直肠癌（CRC）是导致发病率/死亡率的重要原因之一。明确关键的研究差距（RG）、优先级和解决方案可以改善患者的预后。

近期，一篇发表在杂志GUT上的文章对这一问题进行了剖析。RG分析由患者、临床医生和研究人员（n = 71）构成的多学科小组进行。由八个工作组（WG）组成：发现科学；风险；预防；早期诊断和筛查；病理；治愈性治疗；IV期疾病；和CRC患者一起生活。经过讨论并由一个20人的病人小组进行评估。所有参与者都同意最终名单和研究建议（RR）。

最终总结如下十五个关键的RG：RG1：缺乏概括肿瘤/肿瘤微观/宏观环境的现实模型；RG2：关于遗传/环境/生活方式因素对CRC风险的准确作用的证据不足；RG3：需要进一步进行预防性试验；RG4：缺乏整合不同的预防方法；RG5：缺乏CRC筛选的最佳策略；RG6：缺乏有效的系统进行有创性调查；RG7：CRC病理评估不精确；RG8：缺乏基因组学、数据科学和病理学方面的专业人员；RG9：对治疗选择的风险、收益和不确定性的评估/沟通不足；RG10：需要新技术/干预措施来改善疗效；RG11：缺乏识别转移肿瘤与其微环境之间分子相互作用的方法；RG12：缺乏可靠的生物标志物来指导IV期患者的治疗；RG13：需要增加对健康相关生活质量（HRQOL）的理解并促进残留症状的解决；RG14：CRC研究/资助缺乏相互协调；RG15：利益相关者之间缺乏有效的沟通。

此文提出，确定研究活动和资金的优先次序可能会对未来5年减少CRC疾病负担产生重大影响。

原始出处：
Lawler M, Alsina D, et al. Critical research gaps and recommendations to inform research prioritisation for more effective prevention and improved outcomes in colorectal cancer. Gut. 2018 Jan;67(1):179-193. doi: 10.1136/gutjnl-2017-315333.

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学习一下很不错

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学习一下很不错

52 0
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23:52:00 CST 2018, time=2018-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=303528, encodeId=b6a6303528fd, content=学习一下很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/23/ac01daf0962458a9eb8c0b1e2f6ce5bc.jpg, createdBy=04b81710322, createdName=1771ae4158m, createdTime=Sat Apr 07 10:00:37 CST 2018, time=2018-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=294812, encodeId=2f7d2948128a, content=学习一下很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/23/ac01daf0962458a9eb8c0b1e2f6ce5bc.jpg, createdBy=04b81710322, createdName=1771ae4158m, 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2018-03-10 1771ae4158m

学习一下很不错

48 0
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23:52:00 CST 2018, time=2018-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=303528, encodeId=b6a6303528fd, content=学习一下很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/23/ac01daf0962458a9eb8c0b1e2f6ce5bc.jpg, createdBy=04b81710322, createdName=1771ae4158m, createdTime=Sat Apr 07 10:00:37 CST 2018, time=2018-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=294812, encodeId=2f7d2948128a, content=学习一下很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/23/ac01daf0962458a9eb8c0b1e2f6ce5bc.jpg, createdBy=04b81710322, createdName=1771ae4158m, 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2018-03-05 1771ae4158m

学习一下很不错

60 0
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2018-01-05 1771ae4158m

跟大家学习.好

58 0
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attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Sun Dec 17 06:52:00 CST 2017, time=2017-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=269897, encodeId=e12b26989ec9, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sat Dec 16 19:14:24 CST 2017, time=2017-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=269816, encodeId=f15026981671, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, 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2017-12-17 大爰

学习了谢谢分享!!

22 0
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23:52:00 CST 2018, time=2018-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=303528, encodeId=b6a6303528fd, content=学习一下很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/23/ac01daf0962458a9eb8c0b1e2f6ce5bc.jpg, createdBy=04b81710322, createdName=1771ae4158m, createdTime=Sat Apr 07 10:00:37 CST 2018, time=2018-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=294812, encodeId=2f7d2948128a, content=学习一下很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/23/ac01daf0962458a9eb8c0b1e2f6ce5bc.jpg, createdBy=04b81710322, createdName=1771ae4158m, 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2017-12-17 crystal0564

#结直肠#

27 0
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2017-12-16 131****1460

学习了受益匪浅

29 0
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2017-12-16 sunfeifeiyang

学习

24 0