J Periodontal Res:低剂量的ω-3脂肪酸的膳食补充剂可降低慢性牙周炎患者中的TNF-α水平:随机对照临床研究

2017-07-28 MedSci MedSci原创

最近的研究证明了ω-3多不饱和脂肪酸(PUFA)对生理过程和各种慢性炎性疾病(包括牙周病)具有有益作用。在本研究中,我们评估了慢性牙周炎患者ω-3 PUFA结合刮治与根面平整(SRP)对唾液标记物的的影响。

最近的研究证明了ω-3多不饱和脂肪酸(PUFA)对生理过程和各种慢性炎性疾病(包括牙周病)具有有益作用。在本研究中,我们评估了慢性牙周炎患者ω-3 PUFA结合刮治与根面平整(SRP)对唾液标记物的的影响。

方法:将三十个无全身系统性疾病的慢性牙周炎患者随机分为两组。对照组(n = 15)用SRP +安慰剂治疗,而试验组用SRP和膳食补充低剂量ω-3 PUFA(6.25mg二十碳五烯酸和19.19mg二十二碳六烯酸)进行处理。治疗前,治疗后1,3和6 个月分别取临床参数。以相同的时间间隔获取唾液样本,并分析肿瘤坏死因子-α(TNF-α)和超氧化物歧化酶(SOD)。

结果:两组治疗后临床参数均发生显着变化,而两组间差异无统计学意义。与对照组相比,实验组唾液TNF-α水平在6个月时显着降低。与治疗前相比,唾液SOD水平在实验组3,6 个月时显着升高,安慰剂组6 个月时明显升高,而两组间差异无统计学意义。

结论:低剂量ω-3 PUFA的膳食补充剂改善唾液中TNF-α,对慢性牙周炎患者的改善无明显影响,表明膳食ω-3 PUFA的系统性益处可能对牙周健康无明显促进作用。

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    2018-01-22 amyloid
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createdBy=8ae138776909, createdName=amyloid, createdTime=Mon Jan 22 23:46:00 CST 2018, time=2018-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779145, encodeId=c5f71e79145df, content=<a href='/topic/show?id=2216130401' target=_blank style='color:#2F92EE;'>#3脂肪酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1304, encryptionId=2216130401, topicName=3脂肪酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, createdName=mhzhuang@stu.e, createdTime=Fri Feb 02 11:46:00 CST 2018, time=2018-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1695670, encodeId=e64316956e0bb, content=<a href='/topic/show?id=89268592854' target=_blank style='color:#2F92EE;'>#膳食补充剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85928, encryptionId=89268592854, topicName=膳食补充剂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e5ef29855394, createdName=zsyan, createdTime=Sat Mar 10 07:46:00 CST 2018, time=2018-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726600, encodeId=e67c1e266008a, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sat Apr 07 02:46:00 CST 2018, time=2018-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1350331, encodeId=09a0135033141, content=<a href='/topic/show?id=224a85904ad' target=_blank style='color:#2F92EE;'>#膳食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85904, encryptionId=224a85904ad, topicName=膳食)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Jul 30 06:46:00 CST 2017, time=2017-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480455, encodeId=93a714804552e, content=<a href='/topic/show?id=647d2615939' target=_blank style='color:#2F92EE;'>#低剂量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26159, encryptionId=647d2615939, topicName=低剂量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=97b17641126, createdName=ms1292405679162969, createdTime=Sun Jul 30 06:46:00 CST 2017, time=2017-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450578, encodeId=10eb14505e83b, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Sun Jul 30 06:46:00 CST 2017, time=2017-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401646, encodeId=a99b140164646, content=<a href='/topic/show?id=17e21e57943' target=_blank style='color:#2F92EE;'>#TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17579, encryptionId=17e21e57943, topicName=TNF)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqjVbfRD4f4vibEcZVcvato8Qib1gGtZJiayXCMFgHrkeErSiaxdYMiabKGxY2an9muxWCkUJbjFPViaC6A/132, createdBy=e4fb2361580, createdName=snowpeakxu, createdTime=Sun Jul 30 06:46:00 CST 2017, time=2017-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368625, encodeId=394813686252f, content=<a href='/topic/show?id=0e30535657b' target=_blank style='color:#2F92EE;'>#慢性牙周炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53565, encryptionId=0e30535657b, topicName=慢性牙周炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c64275, createdName=piaojinhua, createdTime=Sun Jul 30 06:46:00 CST 2017, time=2017-07-30, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1778769, encodeId=14e31e78769a5, content=<a href='/topic/show?id=2216130401' target=_blank style='color:#2F92EE;'>#3脂肪酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1304, encryptionId=2216130401, topicName=3脂肪酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, createdName=mhzhuang@stu.e, createdTime=Fri Sep 15 02:46:00 CST 2017, time=2017-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1775329, encodeId=776e1e75329b0, content=<a href='/topic/show?id=937d46650bf' target=_blank style='color:#2F92EE;'>#对照#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46650, encryptionId=937d46650bf, topicName=对照)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8ae138776909, createdName=amyloid, createdTime=Mon Jan 22 23:46:00 CST 2018, time=2018-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779145, encodeId=c5f71e79145df, content=<a href='/topic/show?id=2216130401' target=_blank style='color:#2F92EE;'>#3脂肪酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1304, encryptionId=2216130401, topicName=3脂肪酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, createdName=mhzhuang@stu.e, createdTime=Fri Feb 02 11:46:00 CST 2018, time=2018-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1695670, encodeId=e64316956e0bb, content=<a href='/topic/show?id=89268592854' target=_blank style='color:#2F92EE;'>#膳食补充剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85928, encryptionId=89268592854, topicName=膳食补充剂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e5ef29855394, createdName=zsyan, createdTime=Sat Mar 10 07:46:00 CST 2018, time=2018-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726600, encodeId=e67c1e266008a, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sat Apr 07 02:46:00 CST 2018, time=2018-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1350331, encodeId=09a0135033141, content=<a href='/topic/show?id=224a85904ad' target=_blank style='color:#2F92EE;'>#膳食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85904, encryptionId=224a85904ad, topicName=膳食)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Jul 30 06:46:00 CST 2017, time=2017-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480455, encodeId=93a714804552e, content=<a href='/topic/show?id=647d2615939' target=_blank style='color:#2F92EE;'>#低剂量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26159, encryptionId=647d2615939, topicName=低剂量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=97b17641126, createdName=ms1292405679162969, createdTime=Sun Jul 30 06:46:00 CST 2017, time=2017-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450578, encodeId=10eb14505e83b, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Sun Jul 30 06:46:00 CST 2017, time=2017-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401646, encodeId=a99b140164646, content=<a href='/topic/show?id=17e21e57943' target=_blank style='color:#2F92EE;'>#TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17579, encryptionId=17e21e57943, topicName=TNF)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqjVbfRD4f4vibEcZVcvato8Qib1gGtZJiayXCMFgHrkeErSiaxdYMiabKGxY2an9muxWCkUJbjFPViaC6A/132, createdBy=e4fb2361580, createdName=snowpeakxu, createdTime=Sun Jul 30 06:46:00 CST 2017, time=2017-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368625, encodeId=394813686252f, content=<a href='/topic/show?id=0e30535657b' target=_blank style='color:#2F92EE;'>#慢性牙周炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53565, encryptionId=0e30535657b, topicName=慢性牙周炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c64275, createdName=piaojinhua, createdTime=Sun Jul 30 06:46:00 CST 2017, time=2017-07-30, status=1, ipAttribution=)]
    2018-04-07 feather89
  6. [GetPortalCommentsPageByObjectIdResponse(id=1778769, encodeId=14e31e78769a5, content=<a href='/topic/show?id=2216130401' target=_blank style='color:#2F92EE;'>#3脂肪酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1304, encryptionId=2216130401, topicName=3脂肪酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, createdName=mhzhuang@stu.e, createdTime=Fri Sep 15 02:46:00 CST 2017, time=2017-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1775329, encodeId=776e1e75329b0, content=<a href='/topic/show?id=937d46650bf' target=_blank style='color:#2F92EE;'>#对照#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46650, encryptionId=937d46650bf, topicName=对照)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8ae138776909, createdName=amyloid, createdTime=Mon Jan 22 23:46:00 CST 2018, time=2018-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779145, encodeId=c5f71e79145df, content=<a href='/topic/show?id=2216130401' target=_blank style='color:#2F92EE;'>#3脂肪酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1304, encryptionId=2216130401, topicName=3脂肪酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, createdName=mhzhuang@stu.e, createdTime=Fri Feb 02 11:46:00 CST 2018, time=2018-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1695670, encodeId=e64316956e0bb, content=<a href='/topic/show?id=89268592854' target=_blank style='color:#2F92EE;'>#膳食补充剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85904, encryptionId=224a85904ad, topicName=膳食)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Jul 30 06:46:00 CST 2017, time=2017-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480455, encodeId=93a714804552e, content=<a href='/topic/show?id=647d2615939' target=_blank style='color:#2F92EE;'>#低剂量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26159, encryptionId=647d2615939, topicName=低剂量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=97b17641126, createdName=ms1292405679162969, createdTime=Sun Jul 30 06:46:00 CST 2017, time=2017-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450578, encodeId=10eb14505e83b, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Sun Jul 30 06:46:00 CST 2017, time=2017-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401646, encodeId=a99b140164646, content=<a href='/topic/show?id=17e21e57943' target=_blank style='color:#2F92EE;'>#TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17579, encryptionId=17e21e57943, topicName=TNF)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqjVbfRD4f4vibEcZVcvato8Qib1gGtZJiayXCMFgHrkeErSiaxdYMiabKGxY2an9muxWCkUJbjFPViaC6A/132, createdBy=e4fb2361580, createdName=snowpeakxu, createdTime=Sun Jul 30 06:46:00 CST 2017, time=2017-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368625, encodeId=394813686252f, content=<a href='/topic/show?id=0e30535657b' target=_blank style='color:#2F92EE;'>#慢性牙周炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53565, encryptionId=0e30535657b, topicName=慢性牙周炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c64275, createdName=piaojinhua, createdTime=Sun Jul 30 06:46:00 CST 2017, time=2017-07-30, status=1, ipAttribution=)]
    2017-07-30 zhaojie88
  7. 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  8. 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  9. 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createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqjVbfRD4f4vibEcZVcvato8Qib1gGtZJiayXCMFgHrkeErSiaxdYMiabKGxY2an9muxWCkUJbjFPViaC6A/132, createdBy=e4fb2361580, createdName=snowpeakxu, createdTime=Sun Jul 30 06:46:00 CST 2017, time=2017-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368625, encodeId=394813686252f, content=<a href='/topic/show?id=0e30535657b' target=_blank style='color:#2F92EE;'>#慢性牙周炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53565, encryptionId=0e30535657b, topicName=慢性牙周炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c64275, createdName=piaojinhua, createdTime=Sun Jul 30 06:46:00 CST 2017, time=2017-07-30, status=1, ipAttribution=)]
    2017-07-30 snowpeakxu
  10. 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J Clin Periodontol:慢性牙周炎疾病特异性量表的制定和验证

目的:这项研究的目的是制定和验证首个慢性牙周炎特异性相关的口腔健康相关生活质量(OHRQoL)量表,并将其用作临床试验的结果指标。

Sci Rep:孕期口腔感染可促进其慢性牙周炎的发生

关于慢性牙周炎孕妇其口腔内疱疹病毒与牙周可疑致病菌的研究甚少。本次病例对照研究旨在探究慢性牙周炎孕妇其牙周可疑致病菌与疱疹病毒之间的潜在关系。研究共纳入36名慢性牙周炎孕妇和36名牙周健康孕妇,收集唾液样品。检测唾液中六种牙周可疑致病菌(牙龈卟啉单胞菌,伴放线聚集杆菌,具核梭杆菌,中间普氏菌,福赛坦氏菌,和齿垢密螺旋体)和三种疱疹病毒(爱泼斯坦-巴尔病毒,人巨细胞病毒和单纯疱疹病毒)。同时收集所有

Laryngoscope:口腔卫生差,警惕涎石病的发生

Laryngoscope:口腔卫生差,警惕涎石病的发生尽管普遍认为较差的口腔卫生可导致涎石病的发展,但是却鲜有研究支持此观点。因此,本研究旨在基于覆盖全国的数据库评估慢性牙周炎和日后唾液腺结石发生之间的关系。研究采用病例对照研究。共纳入987名涎石病患者。再按5:1(健康者:患者)的比例纳入4935名健康者,匹配性别和年龄。使用条件Logistic回归分析确定涎石病与慢性牙周炎之间的关系。结果发现

J Clin Periodontol:牙周手术治疗联合抗生素光动力疗法对慢性牙周炎的疗效:一种随机对照临床试验

目的:该随机对照临床试验评估重度慢性牙周炎(SCP)患者手术牙周治疗(ST)辅助单次应用抗微生物光动力治疗(aPDT)的效果。

Quintessence Int:牙科医生遇到患者爽约,不要只埋怨患者医生也要反思一下

Quintessence Int:牙科医生遇到患者爽约,不要只埋怨患者医生也要反思一下本研究旨在确定慢性牙周炎患者的依从性与牙周非手术治疗疗效之间的关系,并探讨影响慢性牙周炎患者依从性的因素,从而确定患者的预后并提高治疗的疗效。研究共纳入了400名慢性牙周炎患者,分为三组:完全依从组(S1),依从性一般组(S2),和完全不依从组(S3)。S1组患者按时接受牙周支持治疗(SPT):在不足2个月的治疗