APA 2016:ECT可有效治疗精神分裂症,但仍需进一步的研究

2016-05-24 MedSci MedSci原创

据2016年美国精神病学会年会上展示的一项新的研究表明,电休克疗法可有效治疗精神分裂症,但是可对某些患者的认知产生不良影响。原始出处:Amanda Oldt. ECT effective for schizophrenia, but requires further research. Healio, May 24, 2016.

据2016年美国精神病学会年会上展示的一项新的研究表明,电休克疗法可有效治疗精神分裂症,但是可对某些患者的认知产生不良影响。

“精神分裂症是一种慢性疾病,常表现为妄想、幻觉等,”Tyler Kaster博士,来自多伦多大学,在会议上说道,“大多数治疗指南推荐抗精神病药物为其主要治疗方法。然而,不幸的是,相当一部分抗精神病药物的治疗效果并不理想。有些人认为,电休克治疗(ECT)或可用于治疗该疾病。然而,目前关于使用ECT治疗精神分裂症的研究相当有限。”

为了评估ECT治疗精神分裂症对患者临床疗效和认知功能的影响,研究人员分析了144名精神分裂症或情感分裂性精神障碍患者的临床记录,这些患者接受了171次ECT急性疗程治疗。

总体而言,76.7%的患者对ECT的治疗有反应。

治疗反应与未使用抗癫痫药物(17.9% vs. 3.9%,P = 0071),既往对ECT治疗反应良好(36.4% vs. 15.4%,P = 0174)以及除了药物治疗失败对ECT治疗有一个主要指标(89.7% vs. 69.8%,P = 0174)有关。治疗反应与年龄、氯氮平或地西泮治疗无关。

9%的患者经ECT治疗后出现不良的认知影响,并没有其他临床因素与不良的认知影响有关。

“ECT是治疗精神分裂症的有效急性治疗方法。本研究中四分之三的患者对这种治疗有反应,这种治疗缺失也可导致轻微的认知障碍。但是,我认为ECT治疗仍然十分重要,尽管它存在此副作用。因此,我们还发现一些与治疗反应相关的因素,这或有助于选择接受这项治疗的患者,”Kaster 说道,“本研究突出了这样一个事实,ECT是正忍受症状煎熬的患者的一个重要的治疗选择。”

原始出处:

Amanda Oldt. ECT effective for schizophrenia, but requires further research. Healio, May 24, 2016.

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