Stroke:脑血管痉挛后的升压治疗可致可逆性后部脑病综合征

2015-12-25 phylis 译 MedSci原创

背景和目的:迟发型脑缺血和脑血管痉挛是动脉瘤性蛛网膜下腔出血(SAH)后常见的继发神经损伤。3H疗法,包括高血压,高血容量及血液稀释常用来治疗脑血管痉挛。然而,高血压治疗可能带来严重的并发症,包括心肺,肾,颅内并发症。在高血压状态下,作为可逆性的颅内并发症后可逆性脑病综合症(PRES)的报道较少。方法:研究者对SAH相关性脑痉挛后所致的高血压患者发生PRES进行阐述,并进行系统性回顾。此外,搜索电

背景和目的:迟发型脑缺血病和脑血管痉挛是动脉瘤性蛛网膜下腔出血(SAH)后常见的继发神经损伤。3H疗法,包括扩容(hypervolemia)、血液稀释(hemodilution)和升高血压(hypertension),常被用来治疗脑血管痉挛。然而,高血压治疗可能带来严重的并发症,包括心肺、肾、颅内并发症。在高血压状态下,作为可逆性的颅内并发症——可逆性后部脑病综合征(PRES)的报道较少。

方法:研究者对SAH相关性脑痉挛后所致的高血压患者发生PRES进行了系统性回顾,并进行阐释。此外,搜索电子数据库MEDLINE中高血压后发生PRES的研究。

结果:7篇报道中,共有10个患者高血压后发生PRES。82%的患者为女性。在诊断为PRES之前,主要为脑血管痉挛所致临床症状。从高血压到发展为PRES的时间为7.8±3.8天。诊断为PRES后,进行降血压,所有患者的神经症状在几天之内几乎完全消失。

结论:SAH后为治疗血管痉挛后升压治疗继发的PRES,是一个被忽视的并发症。然而,这种现象的诊断是关键的,因为要逆转高血压,而升压治疗又是血管痉挛的患者的常规处理方式。

原文出处:

Muhammad S, Güresir Á, Greschus S, et al. Posterior Reversible Encephalopathy Syndrome as an Overlooked Complication of Induced Hypertension for Cerebral Vasospasm: Systematic Review and Illustrative Case. Stroke. 2015 Dec 1.


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    2016-11-30 showtest
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    2015-12-27 apoenzyme
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