NAT COMMUN:临床试验证明小分子可能改善心血管衰老

2018-04-03 海北 MedSci原创

最近,来自科罗拉多大学博尔德分校的研究人员在一个2×6周的随机,双盲,安慰剂对照,交叉临床试验中找到了证据。

烟酰胺腺嘌呤二核苷酸(NAD +)已经被证明是参与热量限制的有益作用的酶的关键底物。因此,有研究人员提出,可以使用NAD +前体来增加NAD +的生物利用度,以改善人类衰老的心血管和其他生理功能。

最近,来自科罗拉多大学博尔德分校的研究人员在一个2×6周的随机,双盲,安慰剂对照,交叉临床试验中找到了证据。在健康的中年人和老年人中,长期补充NAD +前体维生素,烟酰胺核糖核苷(NR),的耐受性良好,并且可以有效地刺激NAD+的代谢。

因此,该研究结果提供了对慢性NR补充剂影响人体生理功能的初步了解,同时,其也表明,在未来的临床试验中,应该进一步评估NR在降低血压和缓解动脉僵硬度方面的潜在益处。

原始出处:
Christopher R. Martens et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nature Communication, 2018, DOI: 10.1038/s41467-018-03421-7

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    2018-05-23 宋威
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    2019-01-31 liye789132251
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    2018-06-08 liuli5079
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    2018-04-05 jihuaijun1112

    学习学习学习

    0

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    2018-04-04 flysky120

    心血管衰老的改善.对心衰有好处的

    0

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    2018-04-03 龙胆草

    学习谢谢分享

    0

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