JACC:老年人主动脉瓣置换术后的虚弱状况评估

2017-07-10 xiangting MedSci原创

虚弱是TAVR和SAVR后死亡和残疾的危险因素。

虚弱是一种老年综合征,可削弱经导管主动脉瓣置换术(TAVR)或手术主动脉瓣置换术(SAVR)后的功能恢复潜力。然而其在临床实践中的应用受到如何对其进行测量没有共识的限制。

这项研究旨在比较7种不同的虚弱量表预测TAVR或SAVR后不良结局的增量预计值。

2012年至2016年在3个国家的14个中心进行了一项TAVR或SAVR后老年人的前瞻性队列研究。比较了以下虚弱量表:Fried,Fried+,Rockwood,Short Physical Performance Battery,Bern,Columbia和Essential Frailty Toolset(EFT)。结局是术后1年的全因死亡率和残疾率。

队列由1,020例中位年龄82岁的患者组成。根据使用的量表,虚弱的患病率从26%到68%不等。EFT测量的虚弱是1年后死亡的最强预测指标(调整后的优势比[OR]:3.72; 95%置信区间[CI]:2.54至5.45),C统计值改善0.071(p <0.001)整体鉴别改善0.067(p <0.001)。此外,EFT是1年内残疾加重(调整后OR:2.13; 95%CI:1.57至2.87)和30天死亡(调整后OR:3.29; 95%CI:1.73至6.26)的预测指标。

虚弱是TAVR和SAVR后死亡和残疾的危险因素。包括下肢虚弱,认知功能障碍,贫血和低白蛋白血症的简明4项量表优于其他虚弱量表,推荐在此种情况下使用。

原始出处:

Jonathan Afilalo,et al. Frailty in Older Adults Undergoing Aortic Valve Replacement The FRAILTY-AVR Study. JACC. 7 July 2017.

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

 

 

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    2018-03-19 owlhealth

    不错耶.学习了

    0

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    2017-12-14 hbwxf
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    2018-03-20 yxch48
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  意大利学者的一项真实世界队列研究表明,在手术中危风险的主动脉狭窄患者中,经股动脉导管主动脉瓣置换(TF-TAVR)和手术主动脉瓣置换(SAVR)的死亡率相似,但围手术期并发症表现各异。论文于2012年10月31日在线发表于《美国心脏杂志》(Am Heart J)。   此项研究共纳入182例经股动脉途径接受TAVR的患者和111例接受SAVR的中高危对照患者。基于临床特征

J Am Soc Echocardiogr:主动脉狭窄低血流量相关因素

背景:与正常血流量AS相比,低流量低梯度主动脉狭窄(AS)是不良预后的预测因子。尽管左室射血分数(LVEF)与低流量相关,有关心脏结构和功能的其他指标与的较少。方法:从本地AS患者(≤1 cm2)获得临床和超声心动图的数据,对其进行回顾性分析,识别与低流量低梯度AS相关的特征。结果:共纳入941例患者。在多变量分析中,与低流量相关的独立因素(心搏指数<35mL/m2)包括严重右心室收缩功能降低,心

Heart:失代偿性主动脉狭窄的紧急治疗!

在这个多中心队列中,进行eTAVI和eBAV的即刻和30天的死亡率很高,并且eBAV后eTAVI治疗的死亡率也高于预期。随机对照研究的数据需要确定紧急eTAVI在当前设备的三级医疗中心中的作用。

Int J Cardiol:王建安教授发现严重瓣膜疾病中,二尖瓣反流常见

疾病也是与时俱进的,为了更好了解当前严重瓣膜性疾病的患病情况,浙江大学附属第二医院王建安等进行了一项医院为基础的调查。结果表明,严重瓣膜性疾病在人群中并不少见,其发病原因在<65岁和≥65岁人群有所差异,前者多为风湿热引起,后者多为退行性病变;前者更多见原发性二尖瓣反流,而后者继发性二尖瓣反流更为多见。 研究显示,在严重瓣膜性心脏病中,二尖瓣反流最为常见,患病率为0.68%;二尖瓣狭窄患

NEJM:主动脉狭窄中危患者,TVAR or 主动脉瓣膜置换术?

既往研究已经表明,主动脉狭窄的高危患者,经导管主动脉瓣置换术(TAVR)与主动脉瓣膜置换术的患者生存率相似。本研究旨在通过一项随机试验来评估两种方法对主动脉狭窄的中危患者的疗效。

BMJ Open Heart:高敏C反应蛋白可作为轻度中度主动脉瓣狭窄患者降脂的预后指标

在“辛伐他汀、依泽替米贝在主动脉狭窄中应用”实验(Simvastatin and Ezetimibe in Aortic Stenosis ,SEAS)中,为了评估轻到重度主动脉瓣狭窄的患者在使用上述药物或安慰剂后高敏C反应蛋白在患者的预后的预测价值。研究人员对SEAS中1620个患者进行了分组研究。    在1620个SEAS患者中,研究者测量了他们的血脂