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Eur Respir J：早期联合治疗降低肺动脉高压右心室容积！

2017-07-09 xing.T MedSci原创

早期联合治疗肺动脉高压右心室容积
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由此可见，在PAH患者中，早期联合治疗与改善右心室容量有关。

在肺动脉高压（PAH）患者中，早期联合治疗与更好的临床结局和N-末端脑钠肽前体（NT-proBNP）降低更低相关，相比于单药治疗。NT-proBNP水平反映了右心室（RV）壁应力，当右心室扩张时，NT-proBNP水平增加。近日，呼吸疾病领域权威杂志Eur Respir J上发表了一篇研究文章，该研究旨在探讨早期联合治疗相比于单药治疗对PAH患者右心室容量的影响。这项回顾性研究共纳入了80名发生PAH的患者（ NYHA分级为II和III级），这些患者分别采用前期联合治疗（n=35）（即内皮素受体拮抗剂（ERAs）加磷酸二酯酶-5-抑制剂（PDE5Is））或单药治疗（n=45）（即ERAs或PDE5Is）。所有患者在基线和随访1年后接受了右心导管术和心脏磁共振成像。研究人员发现联合治疗比单药治疗更能显著降低肺血管阻力和肺动脉压力。与单药治疗NT-proBNP降低了51%相比，采用联合治疗NT-proBNP降低了77%（P＜0.001）。联合治疗后右心室容积和计算的右心室壁应力改善（所有P＜0.001），但单药治疗后仍保持不变（两者均为NS）。联合用药组右心室射血分数明显高于单药治疗组（P

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    2018-04-25 jklm09

    #动脉高压#

    0

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    2017-07-11 zhaozuguo

    #联合治疗#

    0

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    2017-07-11 124988c7m99暂无昵称

    #右心室#

    0

  4. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Jul 09 19:58:30 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220389, encodeId=c899220389d9, content=学习了，很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/07/09/550062b3e1463eabc4c924e6927ffe27.jpg, createdBy=01cd1936321, createdName=Mr Banana, createdTime=Sun Jul 09 19:19:01 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220387, encodeId=3f4822038ee7, content=早期联合治疗降低肺动脉高压右心室容积！, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRrYOibkVibW9vAkCfb2F55aHjqMoqUVaF9fuXIMCxexawSOsicpbF7Ria7o54zPK65PodlkwhPrNhLhS/0, createdBy=12f71314239, createdName=ann y, createdTime=Sun Jul 09 18:57:05 CST 2017, time=2017-07-09, status=1, ipAttribution=)]
    2017-07-10 虈亣靌

    讲解的非常好,值得学习

    0

  5. 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    2017-07-10 Y—xianghai

    学习了新知识

    0

  6. 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    2017-07-10 1e0ece0dm09(暂无匿称)

    谢谢分享

    0

  7. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K46ZAxBHmHsph32KkfsWGwmickB6RsCUD8KruE4vo5CpvXfdu16GBpp4ibh6WJu1o9iatP1LWKDmvmic/0, createdBy=be6f1940165, createdName=1e0ece0dm09(暂无匿称), createdTime=Mon Jul 10 07:33:18 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220443, encodeId=d1ee220443f2, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Sun Jul 09 23:35:29 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220400, encodeId=f56d2204003b, content=不错的，学习了！谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Jul 09 19:58:30 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220389, encodeId=c899220389d9, content=学习了，很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/07/09/550062b3e1463eabc4c924e6927ffe27.jpg, createdBy=01cd1936321, createdName=Mr Banana, createdTime=Sun Jul 09 19:19:01 CST 2017, time=2017-07-09, status=1, ipAttribution=), 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    2017-07-09 189****7206

    学习了受益匪浅

    0

  8. 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    2017-07-09 虈亣靌

    不错的，学习了！谢谢分享！

    0

  9. 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    2017-07-09 Mr Banana

    学习了，很不错

    0

  10. 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GetPortalCommentsPageByObjectIdResponse(id=220387, encodeId=3f4822038ee7, content=早期联合治疗降低肺动脉高压右心室容积！, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRrYOibkVibW9vAkCfb2F55aHjqMoqUVaF9fuXIMCxexawSOsicpbF7Ria7o54zPK65PodlkwhPrNhLhS/0, createdBy=12f71314239, createdName=ann y, createdTime=Sun Jul 09 18:57:05 CST 2017, time=2017-07-09, status=1, ipAttribution=)]
    2017-07-09 ann y

    早期联合治疗降低肺动脉高压右心室容积！

    0

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