Circ Cardiovasc Qual Outcomes:精神压力或可增加心血管事件风险

2018-09-21 佚名 嘉音

8月28日,在线发表于《Circ Cardiovasc Qual Outcomes》杂志上的一项研究表明,45岁及以上的中年人若有精神压力,其心肌梗死(MI)和卒中风险也会增加。

8月28日,在线发表于《Circ Cardiovasc Qual Outcomes》杂志上的一项研究表明,45岁及以上的中年人若有精神压力,其心肌梗死(MI)和卒中风险也会增加。

糟糕的精神状况会对身体健康有负面影响,为了进一步加强相关证据,英国爱丁堡大学的Caroline A. Jackson博士及其同事分析了2006~2009年新南威尔士追踪研究招募的221677例受试者的数据,这些受试者没有MI或卒中史。这一人群中,102039例为女性受试者(平均年龄62岁),其余为男性(平均年龄60岁)。

研究者在研究开始的前四周内,通过使用10项凯斯勒心理压力量表评估了这些受试者的心理压力,包括疲劳、焦虑、抑郁和绝望。心理压力评分分为低(分数≤15),中(16~21分),高(22~29分)和非常高(30~50分)四个等级。

在研究开始时,16.2%的受试者的精神压力评分为中等,7.3%受试者的精神压力评分为高或非常高。相比于男性,女性更容易有精神压力(中等评分:17.3% vs. 14.8%;高或非常高的评分:8.1% vs. 6.3%;P < .001)。这些受试者接受了平均4.7年的随访,随访期间,发生了4573例MI事件,2421例卒中事件。

随着精神压力的增加,MI和卒中的绝对风险也增加。在45~79岁的男性受试者中,相比于具有较低精神压力评分的群体,具有高或非常高精神压力评分群体的MI风险增加了30%(HR=1.3;95% CI,1.12-1.51)。而在80岁及以上的受试者中,精神压力的增加与MI风险的增加具有较弱的相关性。在女性受试者中,相比于具有较低精神压力评分的群体,具有高或非常高精神压力评分群体的MI风险增加了18%(HR=1.18;95% CI,0.99-1.42),且这一结果在各个年龄段亚组中具有相似性。在45~79岁的受试者中,具有高或非常高的精神压力评分的男性受试者与女性受试者的卒中风险分别增加了24%(HR=1.24;95% CI,0.97~1.59)和44% (HR=1.44;95% CI,1.09~1.92)。

研究者说:“在45~79岁的受试者中,我们观察到精神压力和男性性别对MI风险的超强交互作用;在女性受试者中,精神压力的巨大效应对卒中的影响更大。另外,调整了普遍存在的混杂因素之后,这样的关联依然存在”。Caroline A. Jackson博士说:“既然生活方式可解释糟糕的精神健康状况与心脏疾病和卒中之间的相关性,那么积极的健康行为对于健康的促进非常重要,特别是在那些有精神压力症状的人群中。”

Caroline A. Jackson博士及其同事认为:“据我们所知,这是关于精神压力与血管发病率的最大规模研究,受试者MI、卒中事件发生数分别是之前所有研究中MI数量的4倍,卒中数量的2倍。”这些研究发现提示,临床工作者应该主动筛查那些有抑郁症和焦虑症状的患者,以及筛选这些患者中的血管疾病风险因素。

原始出处:
Caroline A. Jackson, et al. Psychological Distress and Risk of Myocardial Infarction and Stroke in the 45 and Up Study: A Prospective Cohort Study. Circulation: Cardiovascular Quality and Outcomes. Aug 2018.

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    2019-02-17 quxin068
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    2018-09-24 12282355m97暂无昵称

    学习了

    0

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    2018-09-23 longqijun254
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    2018-09-22 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

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