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JBMR Plus：年龄和剂量对BMP-2给药后基因表达和节段性骨缺损修复的影响

2019-03-06 不详 网络

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众所周知，年龄是影响骨愈合的重要因素，与年龄较大者相比，年龄较小的骨折患者通常可以更快地愈合，并且并发症少。然而，影响年龄对当前骨愈合治疗的反应，例如骨形态发生蛋白2（BMP-2）的递送仍未得到很好的表征。目前尚不清楚如何或是否应修改BMP-2的治疗剂量以解释与年龄相关的差异，以便最小化潜在的不良反应并因此改善患者的骨愈合结果。本研究中，我们试图通过在大鼠中使用临床前大小的节段性骨缺损模型来解决这

众所周知，年龄是影响骨愈合的重要因素，与年龄较大者相比，年龄较小的骨折患者通常可以更快地愈合，并且并发症少。然而，影响年龄对当前骨愈合治疗的反应，例如骨形态发生蛋白2（BMP-2）的递送仍未得到很好的表征。目前尚不清楚如何或是否应修改BMP-2的治疗剂量以解释与年龄相关的差异，以便最小化潜在的不良反应并因此改善患者的骨愈合结果。本研究中，我们试图通过在大鼠中使用临床前大小的节段性骨缺损模型来解决这个问题，以研究在胶原海绵中递送BMP-2后骨修复的年龄相关差异，这是目前的临床标准。

在年轻（7周龄）和成年（8月龄）大鼠中产生股骨缺损，并且使用基因表达分析，纵向放射照相，离体微计算机断层扫描（μCT）以及扭转来评估愈合。结果发现，与成年大鼠相比，幼鼠在1周早期时间点表现出与成骨，软骨形成和基质重塑相关的基因表达升高。这些早期基因表达差异可能影响长期愈合，因为与12周后成年大鼠相比，幼鼠的再生骨显示出更高的骨矿物质密度。此外，当BMP-2剂量从1μg增加至10μg时，幼鼠显示出显着更多的骨形成和增加的机械强度，这一发现在成年大鼠中未观察到。

总体而言，这些结果表明BMP-2介导的骨再生存在年龄相关的差异，包括相对剂量敏感性，这表明年龄是实施BMP-2治疗策略时的重要考虑因素。

原始出处：

Cheng A, Krishnan L, et al., The Effects of Age and Dose on Gene Expression and Segmental Bone Defect Repair After BMP-2 Delivery. JBMR Plus. 2018 Jul 16;3(2):e10068. doi: 10.1002/jbm4.10068. eCollection 2019 Feb.

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    2019-11-12 12498f17m73暂无昵称

    #BMP-2#

    0

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    2019-11-07 HNYYM

    #BMP#

    0

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    2019-10-12 ms9608593228839890

    #Plus#

    0

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    2019-03-07 bioon1

    #基因表达#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1642671, encodeId=500016426e16d, content=<a href='/topic/show?id=814c35e6e2' target=_blank style='color:#2F92EE;'>#BMP-2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3576, encryptionId=814c35e6e2, topicName=BMP-2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=120c22999408, createdName=12498f17m73暂无昵称, createdTime=Tue Nov 12 16:57:00 CST 2019, time=2019-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634065, encodeId=c538163406542, content=<a href='/topic/show?id=596635e549' target=_blank style='color:#2F92EE;'>#BMP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3575, encryptionId=596635e549, topicName=BMP)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d95322064897, createdName=HNYYM, createdTime=Thu Nov 07 05:57:00 CST 2019, time=2019-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2029663, encodeId=ac9b2029663e0, content=<a href='/topic/show?id=fedb14394f4' target=_blank style='color:#2F92EE;'>#Plus#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14394, encryptionId=fedb14394f4, topicName=Plus)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/L2dMhrxjvSWuPWKZZP1I83Rw21EWia7LVTYJibLQkb4oTibrYLwhnAXntTBWR3FruIzKfNMiaBwhYV0AKNmiaNxfialg/132, createdBy=6ea92500119, createdName=ms9608593228839890, createdTime=Sat Oct 12 09:57:00 CST 2019, time=2019-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1348094, encodeId=bf2713480942d, content=<a href='/topic/show?id=d61b418860a' target=_blank style='color:#2F92EE;'>#基因表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41886, encryptionId=d61b418860a, topicName=基因表达)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=bioon1, createdTime=Thu Mar 07 15:57:00 CST 2019, time=2019-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419299, encodeId=0ee81419299b8, content=<a href='/topic/show?id=2e2e10182602' target=_blank style='color:#2F92EE;'>#骨缺损#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101826, encryptionId=2e2e10182602, topicName=骨缺损)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=51173492599, createdName=lfcmxl, createdTime=Thu Mar 07 15:57:00 CST 2019, time=2019-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=362081, encodeId=3df73620811d, content=已阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cd5c2431968, createdName=123ba698m96暂无昵称, createdTime=Wed Mar 06 08:13:32 CST 2019, time=2019-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=362069, encodeId=261536206965, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Wed Mar 06 06:36:47 CST 2019, time=2019-03-06, status=1, ipAttribution=)]
    2019-03-07 lfcmxl

    #骨缺损#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1642671, encodeId=500016426e16d, content=<a href='/topic/show?id=814c35e6e2' target=_blank style='color:#2F92EE;'>#BMP-2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3576, encryptionId=814c35e6e2, topicName=BMP-2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=120c22999408, createdName=12498f17m73暂无昵称, createdTime=Tue Nov 12 16:57:00 CST 2019, time=2019-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634065, encodeId=c538163406542, content=<a href='/topic/show?id=596635e549' target=_blank style='color:#2F92EE;'>#BMP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3575, encryptionId=596635e549, topicName=BMP)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d95322064897, createdName=HNYYM, createdTime=Thu Nov 07 05:57:00 CST 2019, time=2019-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2029663, encodeId=ac9b2029663e0, content=<a href='/topic/show?id=fedb14394f4' target=_blank style='color:#2F92EE;'>#Plus#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14394, encryptionId=fedb14394f4, topicName=Plus)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/L2dMhrxjvSWuPWKZZP1I83Rw21EWia7LVTYJibLQkb4oTibrYLwhnAXntTBWR3FruIzKfNMiaBwhYV0AKNmiaNxfialg/132, createdBy=6ea92500119, createdName=ms9608593228839890, createdTime=Sat Oct 12 09:57:00 CST 2019, time=2019-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1348094, encodeId=bf2713480942d, content=<a href='/topic/show?id=d61b418860a' target=_blank style='color:#2F92EE;'>#基因表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41886, encryptionId=d61b418860a, topicName=基因表达)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=bioon1, createdTime=Thu Mar 07 15:57:00 CST 2019, time=2019-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419299, encodeId=0ee81419299b8, content=<a href='/topic/show?id=2e2e10182602' target=_blank style='color:#2F92EE;'>#骨缺损#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101826, encryptionId=2e2e10182602, topicName=骨缺损)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=51173492599, createdName=lfcmxl, createdTime=Thu Mar 07 15:57:00 CST 2019, time=2019-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=362081, encodeId=3df73620811d, content=已阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cd5c2431968, createdName=123ba698m96暂无昵称, createdTime=Wed Mar 06 08:13:32 CST 2019, time=2019-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=362069, encodeId=261536206965, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Wed Mar 06 06:36:47 CST 2019, time=2019-03-06, status=1, ipAttribution=)]
    2019-03-06 123ba698m96暂无昵称

    已阅

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1642671, encodeId=500016426e16d, content=<a href='/topic/show?id=814c35e6e2' target=_blank style='color:#2F92EE;'>#BMP-2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3576, encryptionId=814c35e6e2, topicName=BMP-2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=120c22999408, createdName=12498f17m73暂无昵称, createdTime=Tue Nov 12 16:57:00 CST 2019, time=2019-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634065, encodeId=c538163406542, content=<a href='/topic/show?id=596635e549' target=_blank style='color:#2F92EE;'>#BMP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3575, encryptionId=596635e549, topicName=BMP)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d95322064897, createdName=HNYYM, createdTime=Thu Nov 07 05:57:00 CST 2019, time=2019-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2029663, encodeId=ac9b2029663e0, content=<a href='/topic/show?id=fedb14394f4' target=_blank style='color:#2F92EE;'>#Plus#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14394, encryptionId=fedb14394f4, topicName=Plus)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/L2dMhrxjvSWuPWKZZP1I83Rw21EWia7LVTYJibLQkb4oTibrYLwhnAXntTBWR3FruIzKfNMiaBwhYV0AKNmiaNxfialg/132, createdBy=6ea92500119, createdName=ms9608593228839890, createdTime=Sat Oct 12 09:57:00 CST 2019, time=2019-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1348094, encodeId=bf2713480942d, content=<a href='/topic/show?id=d61b418860a' target=_blank style='color:#2F92EE;'>#基因表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41886, encryptionId=d61b418860a, topicName=基因表达)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=bioon1, createdTime=Thu Mar 07 15:57:00 CST 2019, time=2019-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419299, encodeId=0ee81419299b8, content=<a href='/topic/show?id=2e2e10182602' target=_blank style='color:#2F92EE;'>#骨缺损#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101826, encryptionId=2e2e10182602, topicName=骨缺损)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=51173492599, createdName=lfcmxl, createdTime=Thu Mar 07 15:57:00 CST 2019, time=2019-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=362081, encodeId=3df73620811d, content=已阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cd5c2431968, createdName=123ba698m96暂无昵称, createdTime=Wed Mar 06 08:13:32 CST 2019, time=2019-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=362069, encodeId=261536206965, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Wed Mar 06 06:36:47 CST 2019, time=2019-03-06, status=1, ipAttribution=)]
    2019-03-06 深海的鱼

    学习学习学习

    0