BMC Ophthalmol:OCT血管造影观察急性眼压升高后前房狭窄患者血管密度的变化

2019-06-28 MedSci 网络

湖州市第一人民医院眼科的Ma ZW等人近日在BMC Ophthalmol杂志上发表了一篇文章。目前尽管尚未完全了解青光眼的发病机制,但眼压升高(IOP)被认为是促进其发展的主要因素。本研究使用光学相干断层扫描血管造影(OCTA)观察到的眼压(IOP)急剧升高,其目的是研究眼压急剧升高后黄斑和视神经乳头(ONH)血管密度的变化。

湖州市第一人民医院眼科的Ma ZW等人近日在BMC Ophthalmol杂志上发表了一篇文章。目前尽管尚未完全了解青光眼的发病机制,但眼压升高(IOP)被认为是促进其发展的主要因素。本研究使用光学相干断层扫描血管造影(OCTA)观察到的眼压(IOP)急剧升高,其目的是研究眼压急剧升高后黄斑和视神经乳头(ONH)血管密度的变化。

这是一项前瞻性对比研究,对前房狭窄的受试者进行激光周边虹膜切开术(LPIs)。在LPI之前和之后1小时测量IOP。使用OCTA在基线和LPI后1小时测量黄斑和ONH的视网膜血管密度。

本研究共纳入了58只眼睛。LPI后平均眼压升高10.5±7.6 mmHg。根据眼压上升的幅度,他们将受试者分为三组:A组= IOP升高≤10mmHg,B组= 10 mmHg IOP升高> 20 mmHg。 A组或B组在急性眼压升高后黄斑区或乳头区血管密度无差异(p> 0.05),但C组有显着性差异(p <0.05)。然而,当受试者未被分组时,ONH和黄斑区域的血管密度在基线和LPI后1小时获得的测量值之间没有差异(p> 0.05)。周围和黄斑血管密度存在相关性(p <0.05)。

因此,研究者认为,在这些具有狭窄前房的受试者中,使用OCTA所检查发现,在LPI后1小时的急性轻度或中度IOP升高不影响黄斑或ONH中的血管密度。然而,当IOP升高大于20 mmHg时,黄斑和乳头血管密度显着下降。

原文出处:

Ma, Z.W., et al., Changes in vessel density of the patients with narrow antenior chamber after an acute intraocular pressure elevation observed by OCT angiography. BMC Ophthalmol, 2019. 19(1): p. 132.

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    2020-04-10 habb
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    2019-06-30 swallow
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    2019-06-30 sodoo
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    2019-06-30 医者仁心
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    2019-06-29 183****7028

    学习

    0

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    2019-06-29 百草

    666

    0