JACC-Heart Failure:未矫正先天性心脏病孕妇的心力衰竭和死亡率

2019-09-19 xing.T MedSci原创

由此可见,该研究的结果表明未经矫正的CHD与矫正后的CHD孕妇心脏状况存在显著差异,结局明显更差,特别是在患有艾森曼格综合征和来自新兴国家的女性。

在全球范围内,先天性心脏病(CHD)是育龄妇女发病率和死亡率的重要原因,未经治疗矫正的CHD女性大型队列数据缺乏。

近日,心血管领域权威杂志JACC-Heart Failure上发表了一篇研究文章,该研究旨在探究未矫正CHD女性的孕产妇和胎儿结局。该研究分析了来自ESC EORP ROPAC登记处未矫正CHD女性的10年数据。

在53个国家共有5739名妊娠妇女,其中3295名妇女患有CHD,其中1059名妇女未进行矫正。其中,41.4%来自新兴国家。未矫正与矫正CHD的女性心脏缺损明显不同,伴有原发性分流病变(44.7% vs. 32.4%)、瓣膜异常(33.5% vs. 12.6%)和法洛四联症/肺闭锁(0.8% vs. 20.3%),p<0.001。在未矫正的CHD女性中,6.8%的患者mWHO风险等级为IV级,约10%患有肺动脉高压(PH),3%的患者在妊娠前出现紫绀。未矫正CHD女性的孕产妇死亡率和心力衰竭(HF)分别为0.7%和8.7%。艾森曼格综合征与心脏事件(65.5%)、孕产妇死亡率(10.3%)和HF(48.3%)的高风险相关。来自新兴国家与较高的孕前HF、PH和紫绀症状发生率(p<0.001)以及较差的孕产妇和胎儿结局相关,心脏事件和胎儿宫内发育迟缓的住院率高出三倍(p<0.001)。

由此可见,该研究的结果表明未经矫正的CHD与矫正后的CHD孕妇心脏状况存在显著差异,结局明显更差,特别是在患有艾森曼格综合征和来自新兴国家的女性。 

原始出处:

Karen Sliwa.et al.Pregnant women with Uncorrected Congenital Heart Disease: Heart failure and mortality.JACC-Heart Failure.2019;http://heartfailure.onlinejacc.org/content/early/2019/09/10/j.jchf.2019.09.001

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    2020-01-14 amy0550
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    2019-12-01 hbwxf
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    2019-09-21 zhaojie88
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    2019-09-21 huirong
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    2019-09-21 slcumt

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