Diabetic Med:2型糖尿病患者的认知功能和结构性大脑异常关系?

2018-12-28 MedSci MedSci原创

2型糖尿病与认知功能障碍有关,但潜在的结构性大脑相关性尚不确定。本研究探讨了长期存在的2型糖尿病患者认知功能与结构性脑异常之间的关系。近日,国际杂志 《Diabetic Med》上在线发表一项关于2型糖尿病患者的认知功能和结构性大脑异常的研究。 本研究包括93名2型糖尿病患者(年龄62.3±5.4岁,糖尿病病程9.7±6.7年; HbA1c 65±10 mmol / mol,8.1±1.3

2糖尿病与认知功能障碍有关,但潜在的结构性大脑相关性尚不确定。本研究探讨了长期存在的2糖尿病患者认知功能与结构性脑异常之间的关系。近日,国际杂志 《Diabetic Med》上在线发表一项关于2糖尿病患者的认知功能和结构性大脑异常的研究。

本研究包括932型糖尿病患者(年龄62.3±5.4岁,糖尿病病程9.7±6.7; HbA1c 65±10 mmol / mol8.1±1.3%)。通过覆盖域内存,处理速度和执行功能的测试评估认知功能。在MRI上自动确定脑组织体积和白质高信号体积。校正年龄,性别和教育程度后进行线性回归分析。

2型糖尿病患者中,白质高信号量增加与处理速度降低有关[回归B系数= -0.22-0.38-0.06),P = 0.009],但与记忆或执行功能无关(P  > 0.05)。脑组织体积与认知功能无显著相关性(P > 0.05)。

在患有长期,严格控制的2型糖尿病的人群中,白质高信号量与处理速度降低有关。这表明脑小血管疾病是这些个体中认知功能障碍的潜在疾病机制。

原始出处:

B. MankovskyN. ZherdovaE. van den Berget al. Cognitive functioning and structural brain abnormalities in people with Type 2 diabetes mellitus

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    2018-12-28 misszhang

    谢谢MedSci提供最新的资讯

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