JACC:孤立性三尖瓣手术的预后研究

2017-12-12 MedSci MedSci原创

孤立性重度三尖瓣疾病的发病率逐年升高,此类疾病预后差,可导致棘手的右心衰。然而,孤立性三尖瓣手术较为少见,且目前尚缺乏手术预后的资料。本研究的目的旨在评估分析孤立性三尖瓣手术预后及其变化趋势。本研究纳入了2004年至2013年年龄大于18岁的接受三尖瓣修复术或置换术的病人,并将患有先心病、心内膜炎和合并其他非冠脉搭桥心脏手术的患者排除在外。最终,十年期间共纳入5005名行孤立性三尖瓣手术的患者,每

孤立性重度三尖瓣疾病的发病率逐年升高,此类疾病预后差,可导致棘手的右心衰。然而,孤立性三尖瓣手术较为少见,且目前尚缺乏手术预后的资料。本研究的目的旨在评估分析孤立性三尖瓣手术预后及其变化趋势。本研究纳入了2004年至2013年年龄大于18岁的接受三尖瓣修复术或置换术的病人,并将患有先心病、心内膜炎和合并其他非冠脉搭桥心脏手术的患者排除在外。最终,十年期间共纳入5005名行孤立性三尖瓣手术的患者,每年手术量从2004年的290例增至2013年的780例(p<0.001),住院死亡率为8.8%,调整后的三尖瓣置换住院死亡率明显高于三尖瓣修复术(OR:1.91; 95% Cl: 1.18 - 3.09; p = 0.009)。研究结果显示,孤立性三尖瓣手术虽然逐年增加,但数量整体来说较少,住院死亡率无明显变化,其中三尖瓣置换术死亡率最高。原始出处:Chad J et al.National Trends and Outcomes in Isolated Tricuspid Valve Surgery.JACC.2017 Dec.本文系梅斯医学(MedSci)原创编译整理,转载需授权!

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    2018-04-30 hbwxf
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    2017-12-12 戒馋,懒,贪

    谢谢分享学习了

    0

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    2017-12-12 flysky120

    学习一下知识了

    0

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目前,对心梗后的左房重塑的认识尚浅。本研究的目的旨在利用心肌梗塞的猪模型来评估左房结构重塑的能力,并阐明左房重塑是如何影响二尖瓣返流的进展。本研究共建立了3个动物模型:1) 近端左回旋支(LCX)包括左房分支冠状动脉闭塞(左房梗塞组);2)近端左回旋支(LCX)不包括左房分支冠状动脉闭塞(LCx组);3)左前降支(LAD)闭塞(LAD组)。通过心脏磁共振扫描对左房、左室重塑和缺血性二尖瓣返流进行评

JACC:依普利酮可减少房颤负担,但不影响心房电重构

醛固酮抑制剂依普利酮(EPL)可以减少收缩型心衰患者房颤的发病风险,然而,其具体机制尚未阐明。本研究将34只房性心动过速的山羊(13 ± 1周)随机分成每日口服EPL组(n=19)和糖片对照组(n=14),主要终点事件是连续七天的房颤(n=29)或持续23周的心动过速(n=5)。结果显示,EPL可以明显减少房颤发展过程中左房的扩张率。与对照组相比,口服EPL的山羊的心房平滑肌肌动蛋白、Ⅲ型胶原表达

JACC:ABSORB Ⅲ期临床试验3年随访结果出炉——生物可吸收支架远期预后不容乐观

可吸收依维莫司洗脱的聚左旋乳酸生物可吸收支架(BVS)可以提供类似于金属药物洗脱支架(DES)的药物作用和机械支撑。ABSORB第3期临床试验将2008名冠心病患者随机分成BVS组和钴铬合金依维莫司洗脱支架(EES)组,随访1年的结果显示了BVS在靶器官损伤(心源性死亡、靶血管心肌梗死和缺血性靶病变血运重建)的非劣效性。本研究的目的旨在评估BVS植入后3年的患者预后结局。随访3年后,复合主要终点事

JACC:低钠联合DASH饮食能显著改善高血压

减少钠的摄入和DASH(Dietary Approaches to Stop Hypertension)饮食(一种富含水果、蔬菜和低脂产品,而饱和脂肪酸和胆固醇较少的食谱)均有降低血压的功能。然而,这些干预方式对基线血压水平的单独和联合效果尚未阐明。本研究的目的旨在比较评估低钠摄入和高钠摄入、DASH饮食和对照、低钠联合DASH饮食和高钠对照饮食对基线收缩压水平的影响。本研究纳入了高血压前期或1期