J Periodontol:局部注射透明质酸填充以改善黑三角

2017-11-11 MedSci MedSci原创

开放的牙龈楔状隙即所谓的黑三角,是成人牙科学中未解决的难题之一。尽管已经引入了各种技术来改善黑三角,但缺乏可重复的实验模型妨碍了成功的方案的龈乳头缺损的再生或补偿。因此,本研究的目的是首先开发一种可靠的开放性牙龈楔状隙的动物模型,然后验证使用透明质酸(HA)填充物来增强龈乳头的微创注射技术。

开放的牙龈楔状隙即所谓的黑三角,是成人牙科学中未解决的难题之一。尽管已经引入了各种技术来改善黑三角,但缺乏可重复的实验模型妨碍了成功的方案的龈乳头缺损的再生或补偿。因此,本研究的目的是首先开发一种可靠的开放性牙龈楔状隙的动物模型,然后验证使用透明质酸(HA)填充物来增强龈乳头的微创注射技术。

方法:通过压缩弹簧构建大鼠下颌切牙间开放牙龈楔状隙,。使用标准化的系列照片,微型计算机断层摄影术和组织切片,形态学评估和计算龈乳头高度的损失。之后,局部注射HA填充剂或磷酸盐缓冲盐水(PBS),并评估龈乳头的变化。

结果:开放7天后,下颌切牙间龈乳头边缘逐渐变得不规则,平坦,与开放性牙龈楔状隙相似(P <0.05)。与注射PBS相比,局部注射HA填充物引起龈乳头的增强作用(P <0.05)。注射后龈乳头凸起,黏膜下层内可见内含HA的内颗粒。

结论:在体内可以可靠地复制开放性的牙龈楔状隙。局部注射HA填充物被证实是一种有意义的改善黑三角的微创手术。

原始出处:

Soojin Pi, et al. Local Injection of Hyaluronic Acid Filler Improves Open Gingival Embrasure: Validation Through a Rat Model. Journal of Periodontology. 2017 November. doi: 10.1902/jop.2017.170101

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    2018-10-03 feather89
  2. [GetPortalCommentsPageByObjectIdResponse(id=1726870, encodeId=ac511e2687085, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Oct 03 06:01:00 CST 2018, time=2018-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=261755, encodeId=069b261e5508, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Thu Nov 16 17:20:48 CST 2017, time=2017-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1276713, encodeId=531112e671375, content=<a href='/topic/show?id=ec9e9482383' target=_blank style='color:#2F92EE;'>#透明质酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94823, encryptionId=ec9e9482383, topicName=透明质酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c77e138, createdName=kalseyzl, createdTime=Mon Nov 13 14:01:00 CST 2017, time=2017-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405771, encodeId=36121405e7104, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Mon Nov 13 14:01:00 CST 2017, time=2017-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260628, encodeId=ccaf2606289c, content=不错的啊文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Sat Nov 11 23:25:43 CST 2017, time=2017-11-11, status=1, ipAttribution=)]
    2017-11-16 Jackie Li

    学习

    0

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    2017-11-13 chg122
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    2017-11-11 1e1b8538m79(暂无匿称)

    不错的啊文章值得推荐

    0