JACC Cardiovasc Imag:无症状性心肌梗死的发病特点及预后

2018-12-18 国际循环编辑部 国际循环

近日,JACC: Cardiovascular Imaging发表一项研究,调查首次急性心肌梗死(AMI)发病患者的无症状性心肌梗死(SMI)患病率及其与长期随访时死亡率和主要不良心血管事件(MACE)的关系。既往研究表明,高达54%的MI发生时无明显症状,但SMI对首次AMI患者发病率和长期预后的意义尚不清楚。 研究纳入2003年~2013年首次AMI发病的392例患者,其在AMI后1

近日,JACC: Cardiovascular Imaging发表一项研究,调查首次急性心肌梗死(AMI)发病患者的无症状性心肌梗死(SMI)患病率及其与长期随访时死亡率和主要不良血管事件(MACE)的关系。既往研究表明,高达54%的MI发生时无明显症状,但SMI对首次AMI患者发病率和长期预后的意义尚不清楚。
 



研究纳入2003年~2013年首次AMI发病的392例患者,其在AMI后14天内进行晚期钆增强心脏磁共振(LGE-CMR)检查。通过在AMI外其他部位鉴定具有缺血分布模式的超增强区域,通过LGE-CMR图像评估SMI。随访(6.8±2.9)年后评估死亡率和MACE(全因死亡,再梗死,冠状动脉旁路移植术和缺血性卒中)。

结果显示,LGE-CMR显示有32例(8.2%)SMI患者。与没有SMI的患者相比,有SMI的患者死亡风险更高(HR=3.87;95%CI:1.21~12.38;P=0.023),MACE风险也是如此(HR=3.10;95%CI:1.22~7.86;P= 0.017),均独立于临床和梗死相关特征。

首次发病的AMI8.2%为SMI,并且与较差的长期临床结局独立相关,死亡率和MACE风险增加3倍。在AMI的情况下,SMI相比传统预后因素具有重要的预后价值,同时提示,这类患者代表了需引起临床重视的高危亚组。

原始出处:
Raquel P. Amier, Martijn W. Smulders, Wiesje M. van der Flier, et al. Long-Term Prognostic Implications of Previous Silent Myocardial Infarction in Patients Presenting With Acute Myocardial Infarction.JACC: Cardiovascular Imaging.Volume 11, Issue 12, December 2018.

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    2019-09-06 hbwxf
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    2019-10-22 quxin068
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    2018-12-20 orangesking

    0

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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Wed Dec 19 09:13:07 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355791, encodeId=953a355e9160, content=谢谢了,学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30331616752, createdName=txqjm, createdTime=Wed Dec 19 06:34:57 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355785, encodeId=11c1355e8529, content=学习了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Tue Dec 18 23:54:15 CST 2018, time=2018-12-18, status=1, ipAttribution=)]
  5. 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  6. 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Wed Dec 19 09:13:07 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355791, encodeId=953a355e9160, content=谢谢了,学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30331616752, createdName=txqjm, createdTime=Wed Dec 19 06:34:57 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355785, encodeId=11c1355e8529, content=学习了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Tue Dec 18 23:54:15 CST 2018, time=2018-12-18, status=1, ipAttribution=)]
    2018-12-20 一天没事干

    很好的学习机会

    0

  7. 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createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/12/cd30eefc465f70dc4dad89bd57479781.jpg, createdBy=02be2318568, createdName=一天没事干, createdTime=Thu Dec 20 08:38:02 CST 2018, time=2018-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355881, encodeId=7e4d35588148, content=8.2%的发生率,由于没有引起重视这部分人群,更是高危亚组。, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ef781002, createdName=topnew, createdTime=Wed Dec 19 22:12:37 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355808, encodeId=10f63558083e, content=无症状心肌梗死, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Wed Dec 19 09:13:07 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355791, encodeId=953a355e9160, content=谢谢了,学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30331616752, createdName=txqjm, createdTime=Wed Dec 19 06:34:57 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355785, encodeId=11c1355e8529, content=学习了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Tue Dec 18 23:54:15 CST 2018, time=2018-12-18, status=1, ipAttribution=)]
    2018-12-19 topnew

    8.2%的发生率,由于没有引起重视这部分人群,更是高危亚组。

    0

  8. 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createdTime=Thu Dec 20 13:35:00 CST 2018, time=2018-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485022, encodeId=15b3148502241, content=<a href='/topic/show?id=4bbe5902ed2' target=_blank style='color:#2F92EE;'>#无症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59027, encryptionId=4bbe5902ed2, topicName=无症状)], attachment=null, authenticateStatus=null, createdAvatar=Bioon/avatar/20180429/70baad2aa5a046c5aa2914d262de7d37.jpg, createdBy=bd077990475, createdName=12498da4m34(暂无昵称), createdTime=Thu Dec 20 13:35:00 CST 2018, time=2018-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355902, encodeId=e2593559024d, content=很好的学习机会, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/12/cd30eefc465f70dc4dad89bd57479781.jpg, createdBy=02be2318568, createdName=一天没事干, createdTime=Thu Dec 20 08:38:02 CST 2018, time=2018-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355881, encodeId=7e4d35588148, content=8.2%的发生率,由于没有引起重视这部分人群,更是高危亚组。, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ef781002, createdName=topnew, createdTime=Wed Dec 19 22:12:37 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355808, encodeId=10f63558083e, content=无症状心肌梗死, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Wed Dec 19 09:13:07 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355791, encodeId=953a355e9160, content=谢谢了,学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30331616752, createdName=txqjm, createdTime=Wed Dec 19 06:34:57 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355785, encodeId=11c1355e8529, content=学习了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Tue Dec 18 23:54:15 CST 2018, time=2018-12-18, status=1, ipAttribution=)]
    2018-12-19 flysky120

    无症状心肌梗死

    0

  9. 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createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/12/cd30eefc465f70dc4dad89bd57479781.jpg, createdBy=02be2318568, createdName=一天没事干, createdTime=Thu Dec 20 08:38:02 CST 2018, time=2018-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355881, encodeId=7e4d35588148, content=8.2%的发生率,由于没有引起重视这部分人群,更是高危亚组。, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ef781002, createdName=topnew, createdTime=Wed Dec 19 22:12:37 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355808, encodeId=10f63558083e, content=无症状心肌梗死, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Wed Dec 19 09:13:07 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355791, encodeId=953a355e9160, content=谢谢了,学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30331616752, createdName=txqjm, createdTime=Wed Dec 19 06:34:57 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355785, encodeId=11c1355e8529, content=学习了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Tue Dec 18 23:54:15 CST 2018, time=2018-12-18, status=1, ipAttribution=)]
    2018-12-19 txqjm

    谢谢了,学习

    0

  10. 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createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/12/cd30eefc465f70dc4dad89bd57479781.jpg, createdBy=02be2318568, createdName=一天没事干, createdTime=Thu Dec 20 08:38:02 CST 2018, time=2018-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355881, encodeId=7e4d35588148, content=8.2%的发生率,由于没有引起重视这部分人群,更是高危亚组。, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ef781002, createdName=topnew, createdTime=Wed Dec 19 22:12:37 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355808, encodeId=10f63558083e, content=无症状心肌梗死, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Wed Dec 19 09:13:07 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355791, encodeId=953a355e9160, content=谢谢了,学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30331616752, createdName=txqjm, createdTime=Wed Dec 19 06:34:57 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355785, encodeId=11c1355e8529, content=学习了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Tue Dec 18 23:54:15 CST 2018, time=2018-12-18, status=1, ipAttribution=)]
    2018-12-18 惠映实验室

    学习了,谢谢分享。

    0

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