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SCI REP：上调颈动脉粥样硬化的芳基硫酸酯酶B与脑栓塞症状相关！

2017-06-28 xing.T MedSci原创

ARSB脑栓塞症状相关性
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这项研究表明ARSB可能代表了一种新的靶标来抑制颈动脉栓塞。

近日，Scientific reports 杂志上发表了一篇研究文章，该研究的目的是确定在颈动脉粥样硬化中哪些基因的表达与脑栓塞症状相关。

研究人员使用GeneSpring11.5分析了两个公开可用的微阵列数据E-MEXP-2257和GSE21545。这两个数据集分别使用了22个和126个颈动脉粥样硬化样本，分别取自有和无脑栓塞症状的患者。为了评估这些结果是否可重复，研究人员采用实时PCR对另外8例脑栓塞症状患者和7例无脑栓塞症状患者的颈动脉粥样硬化样本进行了分析。在血管平滑肌细胞的体外研究来评估一个验证基因的功能相关性。

研究人员使用E-MEXP-2257和GSE21545数据集分确定了1624个和135个在颈动脉粥样硬化样有症状的患者与无症状患者相比差异表达的基因（≥1.15绝对倍数变化，P<0.05）。只有7个差异表达基因或0.4%（7/1752）的基因在两个数据集之间存在一致性。研究人员证实了在动脉粥样硬化有症状的患者中芳基硫酸酯酶B（ARSB）基因的表达差异为1.5倍（P=0.029）。在采用ARSB抑制剂L-抗坏血酸的血管平滑肌细胞体外培养中导致SIRT1和AMPK显著上调。

这项研究表明ARSB可能代表了一种新的靶标来抑制颈动脉栓塞。

原始出处：

Erik Biros,et al. Upregulation of arylsulfatase B in carotid atherosclerosis is associated with symptoms of cerebral embolization.Scientific reports. 2017. https://www.nature.com/articles/s41598-017-04497-9

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    2017-07-20 mhzhuang@stu.e

    #颈动脉#

    0

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    2017-08-19 huangshifeng

    #粥样硬化#

    0

  3. 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    2018-05-18 yige2004

    #栓塞症#

    0

  4. 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    2017-06-30 经常头晕

    #颈动脉粥样硬化#

    0

  5. 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    2017-06-30 axin013

    #脑栓塞#

    0

  6. 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    2017-06-29 海棠胜雪

    学习了

    0

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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuCl4zaE0zq0kFsKQmg3vef7gFticiaFX50TWZibZibNHbk3YSJ5uSh1a0DcUiaVIHkoe2Om3eYg7oUTlf/0, createdBy=442c2063958, createdName=海棠胜雪, createdTime=Thu Jun 29 12:59:43 CST 2017, time=2017-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=216467, encodeId=09ae21646ece, content=介入的风险比较大，根据患者病情及家属的意愿做决定~, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160313/IMG56E50DEC424F44672.jpg, createdBy=ce5b1699635, createdName=Lisa971, createdTime=Wed Jun 28 23:13:42 CST 2017, time=2017-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=216415, encodeId=d25b216415d9, content=在采用ARSB抑制剂L-抗坏血酸的血管平滑肌细胞体外培养中导致SIRT1和AMPK显著上调。, beContent=null, 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    2017-06-28 Lisa971

    介入的风险比较大，根据患者病情及家属的意愿做决定~

    0

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    2017-06-28 有备才能无患

    在采用ARSB抑制剂L-抗坏血酸的血管平滑肌细胞体外培养中导致SIRT1和AMPK显著上调。

    0

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    2017-06-28 131****1460

    学习了受益匪浅。

    0

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GetPortalCommentsPageByObjectIdResponse(id=216394, encodeId=18a6216394dc, content=学习了，谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Wed Jun 28 19:02:17 CST 2017, time=2017-06-28, status=1, ipAttribution=)]
    2017-06-28 1e145228m78(暂无匿称)

    学习了，谢谢作者分享!

    0

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