JACC:左房梗塞对心房重塑的影响

2017-12-10 MedSci MedSci原创

目前,对心梗后的左房重塑的认识尚浅。本研究的目的旨在利用心肌梗塞的猪模型来评估左房结构重塑的能力,并阐明左房重塑是如何影响二尖瓣返流的进展。本研究共建立了3个动物模型:1) 近端左回旋支(LCX)包括左房分支冠状动脉闭塞(左房梗塞组);2)近端左回旋支(LCX)不包括左房分支冠状动脉闭塞(LCx组);3)左前降支(LAD)闭塞(LAD组)。通过心脏磁共振扫描对左房、左室重塑和缺血性二尖瓣返流进行评

目前,对心梗后的左房重塑的认识尚浅。本研究的目的旨在利用心肌梗塞的猪模型来评估左房结构重塑的能力,并阐明左房重塑是如何影响二尖瓣返流的进展。本研究共建立了3个动物模型:1) 近端左回旋支(LCX)包括左房分支冠状动脉闭塞(左房梗塞组);2)近端左回旋支(LCX)不包括左房分支冠状动脉闭塞(LCx组);3)左前降支(LAD)闭塞(LAD组)。通过心脏磁共振扫描对左房、左室重塑和缺血性二尖瓣返流进行评估。研究结果显示,在建模后1周和8周,相比于LCx组和LAD组,左房梗塞组猪的左房扩张更明显,左房功能的损害也更早更严重。缺血性二尖瓣返流在左房梗塞组中更为显着,组织切片结果确证了左房梗塞组心房的广泛梗死和纤维化,而LAD组的猪没有通过心脏磁共振和组织切片观察到左房重塑。本研究首次为急性左房梗塞对心房重塑造成的影响提供了实验证据,急性左房梗塞会引起早期的左房扩张、功能不全、纤维化和二尖瓣返流。原始出处:Jaume A et al.Atrial Infarction and Ischemic Mitral Regurgitation Contribute to Post-MI Remodelin

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    2018-11-18 hbwxf
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    2017-12-12 sodoo
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    2017-12-11 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

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    2017-12-11 wzb521zf

    一起学习一下

    0

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