J Cell Physiol:草莓对子宫肌瘤患者有好处

2019-03-28 佚名 生物通

意大利的研究人员发现,Romina草莓是一个强大的新品种,在体外能够诱导子宫肌瘤细胞的凋亡,其活性成分花青素有望开发成为子宫肌瘤的治疗剂或预防剂。

意大利的研究人员发现,Romina草莓是一个强大的新品种,在体外能够诱导子宫肌瘤细胞的凋亡,其活性成分花青素有望开发成为子宫肌瘤的治疗剂或预防剂。

草莓是一种十分受欢迎的水果。它不仅味道甜美,而且营养丰富。之前有研究表明,草莓中含有的花青素能够降低人们患癌的风险,包括乳腺癌结肠癌、前列腺癌等。于是,意大利的研究人员想了解草莓对子宫肌瘤患者是否有益。

通过一系列研究,他们确认了草莓的健康益处。他们发现,Romina草莓是一个强大的新品种,在体外能够诱导子宫肌瘤细胞的凋亡,其活性成分花青素有望开发成为子宫肌瘤的治疗剂或预防剂。

这篇题为“Romina: A powerful strawberry with in vitro efficacy against uterine leiomyoma cells”的文章发表在《Journal of Cellular Physiology》上。共同通讯作者是意大利马尔凯理工大学的Maurizio Battino和Pasquapina Ciarmela。

子宫肌瘤(uterine leiomyomas)是由子宫平滑肌组织增生而形成的一种常见良性肿瘤,多发生于生育年龄妇女。据统计,30 岁以上的妇女约 20% 患有子宫肌瘤。

在这项研究中,Battino和Ciarmela及其同事收集了五个不同的草莓品种,分别是Alba、Clery、Portola、Tecla和Romina。他们通过测定各个品种的酚类和花青素含量以及抗氧化能力,同时测定子宫肌瘤细胞的凋亡率和活性氧(ROS)生成,从而确定最有效的品种。

他们发现,栽培品种Alba和Romina是最有效的品种,因为它们能够调节氧化磷酸化(耗氧率OCR)、糖酵解(细胞外酸化率ECAR)和纤维化。之后,他们用Alba和Romina提取物以及Romina的花青素成分处理平滑肌瘤和子宫肌层细胞,并用安捷伦Seahorse XF分析仪来测定OCR和ECAR,以及与纤维化相关的基因表达。

研究人员分析后发现,对于平滑肌瘤细胞,Romina花青素在诱导细胞凋亡和降低胞内ROS水平上最有效,其次是Romina和Alba。平滑肌瘤细胞表现出ECAR的明显降低,特别是在Romina花青素处理后。

此外,他们还观察到,Romina及花青素成分处理明显降低了平滑肌瘤细胞中胶原蛋白1A1、纤连蛋白、多能聚糖和激活素A的mRNA表达。

“总之,这项研究表明,Romina草莓及其花青素成分有望开发成子宫肌瘤的治疗剂或预防剂,同时也证实了这些水果及其活性成分的健康益处,”作者总结道。

原始出处:Giampieri F, Islam MS, Greco S, et al. Romina: A powerful strawberry with in vitro efficacy against uterine leiomyoma cells. J Cell Physiol. 2019 May;234(5):7622-7633.

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    2019-06-25 维他命
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    2019-03-30 wgsun

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