Curr Opin Immunol：研究确定牛皮癣发病新机制，这缠人的疾病可能有救了！

2017-12-18 Heather_z727译自 medpageoday 来宝网

发表于《Current Opinion in Immunology》杂志上的一项研究提出了一种新的观点，银屑病和特应性皮炎（AD）来自同一种谱，不是单独的疾病，这一发现有望带来更好的理解和更好的治疗。

发表于《Current Opinion in Immunology》杂志上的一项研究提出了一种新的观点，银屑病和特应性皮炎（AD）来自同一种谱，不是单独的疾病，这一发现有望带来更好的理解和更好的治疗。

来自美国西奈山大学的研究人员表示：“牛皮癣和AD存在整个频谱极性T细胞轴，创造出一些重叠的疾病特征。”

他们指出，当这些T细胞介导的炎症性皮肤病在欧洲的美国人群中进行研究时，它们之间的差异在T细胞极性和细胞因子阵列中都很清楚。银屑病主要是由Th17细胞和IL-17的激活引起的，一个强大的推动力是Th2，这与IL-4和IL-13的产生有关。然而， AD有一个显着的IL-17成分。这一点，再加上与银屑病组织病理学重叠的组织模式，开始建立了一系列免疫疾病的案例，研究人员在报告中进行了详细的描述。

“我们曾经认为，特应性皮炎是一个纯粹的Th2细胞的疾病，但是，现在我们发现它更复杂，它实际上有不同的表型。而Th2细胞活化是这些表型常见形式，我们需要把它作为一个连续性来考虑，对于不同类型的特应性皮炎表型的不同患者亚群，我们需要考虑，可以为牛皮癣的治疗带来新思路”。

作者认为，这种思维方式有助于开发有针对性治疗方法，特别是针对AD的治疗方法。靶向Th2和IL-4/IL-13是特应性皮炎的一种非常有效的策略。从这一点出发，也有助于帮助牛皮癣患者赶走缠人的疾病。

原始出处：EmmaGuttman-Yassky, James GKrueger. Atopic dermatitis and psoriasis: two different immune diseases or one spectrum?. Current Opinion in Immunology. October 2017,

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2018-01-01 135****7952平儿

学了.......

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2017-12-20 1e145228m78(暂无匿称)

学习了谢谢作者分享!

171 0
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2017-12-19 131****2916

不错的文章值得推荐

182 0
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2017-12-19 139****0239

henhao

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2017-12-18 有备才能无患

发表于杂志上的一项研究提出了一种新的观点.银屑病和特应性皮炎(AD)来自同一种谱.不是单独的疾病.这一发现有望带来更好的理解和更好的治疗.

172 0
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2017-12-18 林3301

学习了解一下

139 0
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2017-12-18 衣带渐宽

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