低剂量糖皮质激素可降低严重烧伤患者并发症发生率

2016-08-01 王志勇 郇京宁 中华烧伤杂志

过度全身炎症反应是严重烧伤后一个尚未解决的重要问题。本研究旨在评价低剂量糖皮质激素治疗在下调严重烧伤患者全身炎症反应中的作用。研究共纳入69例70%TBSA及以上面积烧伤患者,其中31例急性期应用低剂量糖皮质激素治疗作为试验组,其余38例未接受前述激素治疗作为对照组。比较2组患者血浆炎症因子水平及临床转归。结果显示,试验组患者肺部感染、应激性溃疡和/或出血的发生率分别为24.2%、3.0%,明显低

过度全身炎症反应是严重烧伤后一个尚未解决的重要问题。本研究旨在评价低剂量糖皮质激素治疗在下调严重烧伤患者全身炎症反应中的作用。


研究共纳入69例70%TBSA及以上面积烧伤患者,其中31例急性期应用低剂量糖皮质激素治疗作为试验组,其余38例未接受前述激素治疗作为对照组。比较2组患者血浆炎症因子水平及临床转归。


结果显示,试验组患者肺部感染、应激性溃疡和/或出血的发生率分别为24.2%、3.0%,明显低于对照组的47.8%、19.6%;住院时间比对照组缩短近13 d;病死率、机械通气时间和脓毒症发生率则与对照组相近。ELISA法检测显示,试验组患者血浆C反应蛋白、TNF–α、IL–6、IL–8水平均明显低于对照组。


研究提示,严重烧伤急性期应用低剂量糖皮质激素可降低促炎细胞因子水平,从而减少肺部感染和应激性溃疡的发生并缩短住院时间。


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    2016-11-23 丁鹏鹏
  3. 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    2017-02-13 萧寒

    受益匪浅

    0

  4. 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objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Thu Oct 13 14:39:13 CST 2016, time=2016-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=125815, encodeId=66811258159c, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Sep 13 22:54:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=125816, encodeId=6ff712581619, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Sep 13 22:54:00 CST 2016, time=2016-09-13, status=1, ipAttribution=)]
    2016-12-12 虈亣靌

    学习了,长见识了

    0

  5. 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objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Thu Oct 13 14:39:13 CST 2016, time=2016-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=125815, encodeId=66811258159c, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Sep 13 22:54:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=125816, encodeId=6ff712581619, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Sep 13 22:54:00 CST 2016, time=2016-09-13, status=1, ipAttribution=)]
    2016-11-30 虈亣靌

    讲的好,学习了

    0

  6. 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GetPortalCommentsPageByObjectIdResponse(id=125816, encodeId=6ff712581619, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Sep 13 22:54:00 CST 2016, time=2016-09-13, status=1, ipAttribution=)]
    2016-11-14 虈亣靌

    讲得好,分享

    0

  7. 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  8. 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    2016-10-13 1e10c84am36(暂无匿称)

    文章真好,喜欢阅读

    0

  9. 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objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Thu Oct 13 14:39:13 CST 2016, time=2016-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=125815, encodeId=66811258159c, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Sep 13 22:54:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=125816, encodeId=6ff712581619, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Sep 13 22:54:00 CST 2016, time=2016-09-13, status=1, ipAttribution=)]
    2016-09-13 doctorJiangchao

    继续学习

    0

  10. 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