Lancet:阿达木单抗持续治疗可降低活动性放射学阴性中轴型脊柱关节炎患者复发风险

2018-06-29 zhangfan MedSci原创

研究发现,接受阿达木单抗单抗治疗后症状缓解的活动性放射学阴性中轴型脊柱关节炎患者,坚持治疗可显著降低疾病复发风险

ABILITY-3研究为大规模III期研究,考察接受阿达木单抗后症状缓解的活动性放射学阴性中轴型脊柱关节炎(nr-axSpA)患者停止治疗后的症状改善情况,近日研究人员公布了其临床研究结果。

成年nr-axSpA患者参与研究,患者在28周治疗后疾病活动性得分(ASDAS)低于1.3,随机接受持续的阿达木单抗治疗或安慰剂,研究的主要终点是无复发,复发的定义为连续2次ASDAS得分大于2.1。

673名患者参与研究,305人(45%)在双盲研究期间得到持续的疾病缓解,持续治疗组152人,停药组153人。68周后,持续治疗组70%的患者vs对照组47%的患者持续疾病缓解。在673名接受过阿达木单抗治疗的人群中,516人(77%)报告了不良事件,其中28人(4%)出现严重不良事件,主要包括鼻咽炎、上呼吸道感染以及轴性关节炎恶化。

研究发现,接受阿达木单抗单抗治疗后症状缓解的活动性放射学阴性中轴型脊柱关节炎患者,坚持治疗可显著降低疾病复发风险。

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    2019-04-17 howi
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    2018-07-01 lmm397
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    2018-07-01 kkunny
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    2018-06-29 wzb521zf

    一起学习学习

    0