Radiology:减肥可减缓关节退行性改变

2017-05-02 tulip1999 来宝网

肥胖是骨关节炎已知的危险因素,是造成美国居民残疾的主要原因之一。一项最新研究提供的证据表明,减肥可以减缓膝关节骨性关节炎的进展,减少膝关节软骨的退化。

肥胖是骨关节炎已知的危险因素,是造成美国居民残疾的主要原因之一。一项最新研究提供的证据表明,减肥可以减缓膝关节骨性关节炎的进展,减少膝关节软骨的退化。

研究人员发现,与没有进行减肥的人群相比,超重或肥胖成年人将体重减轻5%或10%持续四年以上,其膝关节结构的退行性改变明显有所减缓。

该项研究的主要作者,加利福尼亚大学旧金山分校放射科学与生物医学成像系的Alexandra Gersing博士及其同事在《放射学》杂志上报道了他们的最新发现。

骨关节炎(OA),又称退行性关节病,是美国居民最常见的一种关节炎,大约有3,000万多名美国成年人受累。

这种疾病是由于软骨破坏所引起的。

超重或肥胖是骨关节炎(OA)的主要危险因素;多余的体重会给关节和软骨带来额外的压力,造成“磨损”。

此外,Gersing博士及其同事指出,体脂肪过高会增加血液中促炎性物质,增加骨关节炎(OA)风险。

在他们的研究中,研究人员试图去更好地了解体重减轻对关节健康会有什么影响。

“我们仔细查看了所有膝关节结构的退化情况,如半月板、关节软骨以及骨髓等,”Gersing博士指出。

研究人员对640名超重或肥胖的成年人进行了分析。所有参与者均存在骨关节炎(OA)危险因素或经MRI扫描确定患有轻至中度骨关节炎(OA)。

在为期48个月的研究过程中,研究人员监测受试者体重的变化及其膝关节退行性变的情况。

根据他们在这4年期间的体重变化,将参与者分为三组:减重超过10%的成年人,减重在5%-10%的成年人以及体重没有什么变化的成年人(对照组)。

与对照组相比,研究人员发现,减重至少5%的成年人其膝关节软骨变性有所减缓,减缓的程度甚至超过了那些减重超过10%以上的参与者。

“我们的研究中最令人兴奋的发现是,我们不仅能够看到关节软骨退行性变有所减缓,还看到了那些超重和肥胖人群在减重超过5%以上时其半月板退行性变明显减缓,而且减缓的效果明显大于超重者和减重最多者,”Gersing博士说道。

总的来说,研究人员相信,他们的研究结果表明减轻体重如何能够降低超重或肥胖患者的骨关节炎(OA)风险。

“我们的研究强调了个体化治疗策略和生活方式干预的重要性,以便尽早预防肥胖和超重患者发生膝关节退行性变的风险。”Alexandra Gersing博士如是说。

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    2017-05-08 困困困

    学习

    0

  3. 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    2017-05-05 明天会更好!

    学习了,涨知识了

    0

  4. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170110/IMG587462ED91F877489.jpg, createdBy=cf801984270, createdName=多福爱, createdTime=Wed May 03 12:32:32 CST 2017, time=2017-05-03, status=1, ipAttribution=)]
    2017-05-05 1e10eabem79(暂无匿称)

    似乎早己有相关研究发表,创新之处在哪里?

    0

  5. 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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Wed May 03 13:48:13 CST 2017, time=2017-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193263, encodeId=030219326316, content=减肥可以改善好多疾病好像, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Wed May 03 12:53:02 CST 2017, time=2017-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193258, encodeId=a59f19325849, content=看起来减重5-10%关节获益更大。, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170110/IMG587462ED91F877489.jpg, createdBy=cf801984270, createdName=多福爱, createdTime=Wed May 03 12:32:32 CST 2017, time=2017-05-03, status=1, ipAttribution=)]
    2017-05-04 lovetcm

    可以减少关节退变,又一好处

    0

  6. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170110/IMG587462ED91F877489.jpg, createdBy=cf801984270, createdName=多福爱, createdTime=Wed May 03 12:32:32 CST 2017, time=2017-05-03, status=1, ipAttribution=)]
    2017-05-04 hanchunhee

    又一个控制体重的好处。学习了。

    0

  7. 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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Wed May 03 13:48:13 CST 2017, time=2017-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193263, encodeId=030219326316, content=减肥可以改善好多疾病好像, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Wed May 03 12:53:02 CST 2017, time=2017-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193258, encodeId=a59f19325849, content=看起来减重5-10%关节获益更大。, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170110/IMG587462ED91F877489.jpg, createdBy=cf801984270, createdName=多福爱, createdTime=Wed May 03 12:32:32 CST 2017, time=2017-05-03, status=1, ipAttribution=)]
    2017-05-04 flyingzyx

    谢谢分享

    0

  8. 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createdName=hanchunhee, createdTime=Thu May 04 06:42:33 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193479, encodeId=f6fc1934e973, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2SEXGDldsNfP4rKvY7vJmaHcyvLXicuyaCTJtVOkX3jvd6DwNMD88hDjJwsU7MnUH6zeqC4zt3yGV/0, createdBy=4e701628585, createdName=flyingzyx, createdTime=Thu May 04 05:27:45 CST 2017, time=2017-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193278, encodeId=e2d81932e81e, content=非常好的文章,学习了,很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Wed May 03 13:48:13 CST 2017, time=2017-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193263, encodeId=030219326316, content=减肥可以改善好多疾病好像, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Wed May 03 12:53:02 CST 2017, time=2017-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193258, encodeId=a59f19325849, content=看起来减重5-10%关节获益更大。, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170110/IMG587462ED91F877489.jpg, createdBy=cf801984270, createdName=多福爱, createdTime=Wed May 03 12:32:32 CST 2017, time=2017-05-03, status=1, ipAttribution=)]
    2017-05-03 天涯183

    非常好的文章,学习了,很受益

    0

  9. 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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Wed May 03 13:48:13 CST 2017, time=2017-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193263, encodeId=030219326316, content=减肥可以改善好多疾病好像, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Wed May 03 12:53:02 CST 2017, time=2017-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193258, encodeId=a59f19325849, content=看起来减重5-10%关节获益更大。, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170110/IMG587462ED91F877489.jpg, createdBy=cf801984270, createdName=多福爱, createdTime=Wed May 03 12:32:32 CST 2017, time=2017-05-03, status=1, ipAttribution=)]
    2017-05-03 1ddf0692m34(暂无匿称)

    减肥可以改善好多疾病好像

    0

  10. 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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Wed May 03 13:48:13 CST 2017, time=2017-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193263, encodeId=030219326316, content=减肥可以改善好多疾病好像, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Wed May 03 12:53:02 CST 2017, time=2017-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193258, encodeId=a59f19325849, content=看起来减重5-10%关节获益更大。, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170110/IMG587462ED91F877489.jpg, createdBy=cf801984270, createdName=多福爱, createdTime=Wed May 03 12:32:32 CST 2017, time=2017-05-03, status=1, ipAttribution=)]
    2017-05-03 多福爱

    看起来减重5-10%关节获益更大。

    0

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高胆固醇不仅会损害机体的心血管系统。近期发表于FASEB的一项新的研究利用动物模型发现,高胆固醇可引发线粒体对软骨细胞的氧化应激,导致细胞死亡,并最终导致骨关节炎的发生发展。本研究测试了线粒体靶向抗氧化剂在高胆固醇诱导的骨关节炎中潜在的治疗作用,并位使用线粒体靶向抗氧化剂治疗骨关节炎提供证据支持。研究人员使用两种不同的动物模型来模拟人类高胆固醇血症。第一种动物模型是携带改变基因的小鼠,这个基因称为