ATVB:颈动脉斑块钙化与斑块内出血相关!

2017-04-29 xing.T MedSci原创

由此可见,颈动脉粥样硬化斑块表面钙化和多个钙化与IPH存在独立相关,提示钙化数量和位置都可能在IPH的发生中起着重要的作用。这些发现可能为理解IPH的机制提供了新的见解。

颈动脉斑块内出血(IPH)与心血管事件相关。斑块钙化,经常伴随着IPH,可能在IPH的发生中起了一定的作用。近日,心血管领域权威杂志Arteriosclerosis, Thrombosis, and Vascular Biology上发表了一篇研究文章,在这项研究中,研究人员旨在探讨钙化特征与颈动脉斑块IPH之间的相关性。

117例脑血管症状和超声检测有颈动脉斑块的患者被招募入研究,并且进行了增强磁共振成像检查。通过磁共振成像测量的进一步颈动脉斑块组成被纳入分析,颈动脉钙化被分为以下几类:表面钙化、混合钙化和深部钙化。同时根据钙化数量,这些患者被分为单个和多个钙化。采用广义估计方程的Logistic回归模型被用来评价钙化与IPH之间的相关性。

在117名受试者中,有85名受试者共计142处斑块被纳入最后的分析,其中32名受试者因为缺乏斑块组成数据而被排除在外。在这142个斑块中,40个(28.2%)斑块存在IPH。存在IPH的斑块比没有IPH的斑块具有更高的钙化发生率(87.5% vs. 55.9%;P=0.005)。在调整了年龄、低密度脂蛋白、最大管壁厚度、最大软斑块厚度后,研究人员发现多发钙化(比值比为10.1;95%可信区间为3.3-30.4)、表面钙化(比值比为29.4;95%可信区间为4.1-210.8)和混合性钙化(比值比为27.9;95%可信区间为7.3-107.1)与IPH的存在密切相关(所有P<0.05)。

由此可见,颈动脉粥样硬化斑块表面钙化和多个钙化与IPH存在独立相关,提示钙化数量和位置都可能在IPH的发生中起着重要的作用。这些发现可能为理解IPH的机制提供了新的见解。

原始出处:

Ruolan Lin,et al. Association Between Carotid Atherosclerotic Plaque Calcification and Intraplaque Hemorrhage A Magnetic Resonance Imaging Study.ATVB.2017. https://doi.org/10.1161/ATVBAHA.116.308360

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    2017-07-13 gongliu
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    2017-05-02 大爰

    好文章学习并分享!!

    0

  4. 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    2017-05-01 flysky120

    学习一下知识,进步

    0

  5. 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  6. 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  7. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191966, encodeId=29b019196699, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Sun Apr 30 00:14:28 CST 2017, time=2017-04-30, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1977953, encodeId=9dc819e7953e9, content=<a href='/topic/show?id=20411e958de' target=_blank style='color:#2F92EE;'>#TVB#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17958, encryptionId=20411e958de, topicName=TVB)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a5a149, createdName=gongliu, createdTime=Thu Jul 13 02:20:00 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1843457, encodeId=67dd184345e40, content=<a href='/topic/show?id=dab8100523bb' target=_blank style='color:#2F92EE;'>#颈动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100523, encryptionId=dab8100523bb, topicName=颈动脉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191966, encodeId=29b019196699, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Sun Apr 30 00:14:28 CST 2017, time=2017-04-30, status=1, ipAttribution=)]
    2017-04-30 ylzr123

    认真学习,把间接经验应用到临床实践中去,然后再总结出新思路。给点赞啦……

    0

  9. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191966, encodeId=29b019196699, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Sun Apr 30 00:14:28 CST 2017, time=2017-04-30, status=1, ipAttribution=)]
    2017-04-30 1ddf0692m34(暂无匿称)

    钙化之后变硬而容易出血

    0

  10. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191966, encodeId=29b019196699, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Sun Apr 30 00:14:28 CST 2017, time=2017-04-30, status=1, ipAttribution=)]
    2017-04-30 tanxingdoctor

    学习了谢谢分享

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