2019年ADA:口服semaglutide治疗2型糖尿病的心血管安全性可控

2019-06-12 不详 网络

诺和诺德公司近日宣布,PIONEER 6试验通过比较口服semaglutide(胰高血糖素样肽-1类似物)与安慰剂,基于137个首次主要不良心血管事件和16个月的中位随访,证明了semaglutide的主要不良心血管事件(MACE)的非劣性。

诺和诺德公司近日宣布,PIONEER 6试验通过比较口服semaglutide(胰高血糖素样肽-1类似物)与安慰剂,基于137个首次主要不良心血管事件和16个月的中位随访,证明了semaglutide的主要不良心血管事件(MACE)的非劣性。PIONEER 6试验的主要终点为首次发生心血管死亡、非致命性心肌梗死或非致命性卒中MACE复合结果。

PIONEER 6试验的主要结果将在2019年美国糖尿病协会(ADA)会议上发表,并同时发表在新英格兰医学杂志(NEJM)上。


原始出处:

http://www.firstwordpharma.com/node/1646837#axzz5qOw0cfEI

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    2019-06-14 般若傻瓜
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    2019-06-14 fengyi812
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    2019-06-12 misszhang

    谢谢MedSci提供最新的资讯

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研究认为,对于服用二甲双胍效果不佳的II型糖尿病患者,接受每天7或14 mg的Semaglutide治疗,在血糖以及体重控制方面的效果均优于西他列汀

NEJM:Semaglutide不会威胁2型糖尿病患者的心血管安全性

对于2型糖尿病,指南规定新的糖尿病疗法要建立心血管安全性,以排除多余的心血管风险。semaglutide(胰高血糖素样肽1类似物,半衰期延长约1周)对于2型糖尿病患者的心血管作用还是未知的。原始出处:Steven P. Marso,Stephen C. Bain,Agostino Consoli,et al.Semaglutide and Cardiovascular Outcomes in Pa

EASD 2016:诺和诺德semaglutide使高危2型糖尿病患者主要心血管事件风险显著降低26%

糖尿病巨头诺和诺德(Novo Nordisk)近日在德国慕尼黑举行的第52届欧洲糖尿病研究协会(EASD)上公布了该公司正在开发的一款糖尿病新药semaglutide(索马鲁肽)一项III期临床研究(SUSTAIN 6)的新数据。 semaglutide是一种新型长效胰高血糖素样肽-1(GLP-1)类似物,每周皮下注射一次,可使2型糖尿病患者血糖水平大幅改善,并且低血糖风险较低。于此同时,sem

EASD 2016:诺和诺德长效GLP-1降糖药semaglutide三大功效:降糖,减肥,降低心血管风险

糖尿病巨头诺和诺德(Novo Nordisk)近日在德国慕尼黑举行的第52届欧洲糖尿病研究协会(EASD)上公布了该公司正在开发的一款糖尿病新药semaglutide(索马鲁肽)一项III期临床研究(SUSTAIN 5)的新数据。 semaglutide是一种新型长效胰高血糖素样肽-1(GLP-1)类似物,每周皮下注射一次,可使2型糖尿病患者血糖水平大幅改善,并且低血糖风险较低。于此同时,s

Lancet Diabetes Endocrinol:GLP类似物Semaglutide比甘精胰岛素疗法更具优势

GLP类似物Semaglutide对二甲双胍效果不佳的II型糖尿病患者比甘精胰岛素疗法更具优势