Sci Rep:MSCs来源的外泌体或囊泡可保护骨关节炎患者的软骨

2017-12-09 MedSci MedSci原创

间充质干细胞或基质细胞(MSCs)可在骨关节炎(OA)患者中发挥软骨保护作用。其作用发挥主要是通过可溶性介质介导的,这些介质可以在细胞外囊泡(EVs)内传递。本研究旨在比较外泌体(Exos)或微泡/微粒(MP)在OA中的作用。通过差速离心从小鼠骨髓BM-MSC中分离MPs和Exos。评估MPs或Exos对OA样小鼠软骨细胞的作用,并通过RT-qPCR定量软骨保护素。结果显示,在OA样软骨细胞中,B

间充质干细胞或基质细胞(MSCs)可在骨关节炎(OA)患者中发挥软骨保护作用。其作用发挥主要是通过可溶性介质介导的,这些介质可以在细胞外囊泡(EVs)内传递。本研究旨在比较外泌体(Exos)或微泡/微粒(MP)在OA中的作用。

通过差速离心从小鼠骨髓BM-MSC中分离MPs和Exos。评估MPs或Exos对OA样小鼠软骨细胞的作用,并通过RT-qPCR定量软骨保护素。结果显示,在OA样软骨细胞中,BM-MSCs来源的MPs和Exos可以在抑制分解代谢(MMP-13,ADAMTS5)和炎性(iNOS)标志物的同时重新诱导软骨细胞标志物(II型胶原蛋白,聚集蛋白聚糖)的表达。此外,研究还显示,Exos和MPs可保护软骨细胞免于凋亡并抑制巨噬细胞活化。在体内,将Exos或MPs注射到胶原酶诱导的OA(CIOA)模型中,并通过μCT和共聚焦激光显微术进行关节组织形态计量学分析。结果显示,BM-MSCs、MPs和Exos在保护小鼠免受关节损伤方面效果相同。

综上所述,该研究结果表明,MPs和Exos在体外表现出类似的软骨保护和抗炎功能,并可保护小鼠免于发生OA,这表明Exos或MPs产生了BM-MSCs的主要治疗效果。

原始出处:

Cosenza S, Ruiz M, et al., Mesenchymal stem cells derived exosomes and microparticles protect cartilage and bone from degradation in osteoarthritis. Sci Rep. 2017 Nov 24;7(1):16214. doi: 10.1038/s41598-017-15376-8.

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    2018-06-01 lisa438
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    2017-12-11 lmm397
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    2017-12-11 huanbaofeng
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    2017-12-11 zhanfl
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    2017-12-09 清风拂面

    谢谢分享.学习了

    0

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