Circ-Cardiovasc Inte:经皮冠状动脉造影术后急性肾损伤的预防策略!

2017-05-10 xing.T MedSci原创

在接受经皮冠状动脉操作的患者中,相比于生理盐水,他汀类药物与CIAKI风险显著降低相关,并且多个研究结果一致。虽然黄嘌呤、NAC、NaHCO3、NAC+NaHCO3、缺血预处理和钠尿肽可能具有保护作用,但在多个敏感性分析中这些结果并不一致。

目前针对造影剂诱导的急性肾损伤(CIAKI)可用的有效预防策略的疗效仍是一个存在争议的问题。近日,心血管领域权威杂志Circulation: Cardiovascular Interventions上针对这一问题发表了一篇研究文章。

研究人员对比较了10种策略的124项试验(28240例参与者)进行了一个贝叶斯随机效应网络荟萃分析。这10种策略包括:盐水、N-乙酰半胱氨酸(NAC)、他汀类药物、碳酸氢钠(NaHCO3),NAC+NaHCO3、抗坏血酸、黄嘌呤、多巴胺药物、外周缺血预处理和钠尿肽。

与生理盐水相比,采用他汀类药物(比值比[OR]为0.42;95%可信区间[CI]为0.26-0.67)、黄嘌呤(OR为0.32;95%CI为0.17-0.57)、缺血预处理(OR为0.48;95% CI为0.26-0.87),NAC+NaHCO3(OR为0.50;95% CI为0.33-0.76)、NAC(OR为0.68;95% CI为0.55-0.84),和碳酸氢钠(OR为0.66;95% CI为0.47-0.90)处理CIAKI风险有所降低。在跨多个敏感性分析中,他汀类药物治疗的好处是一致的,而所有其他策略的疗效均受到了质疑,通过限定分析高质量的试验。

总体而言,涉及黄嘌呤和缺血预处理的比较可以观察到较高的异质性,虽然NAC和黄嘌呤的影响可能是受到发表偏倚/研究效果较小的影响。单独进行水化是预防CIAKI效果最差的策略。Meta回归没有发现基础肌酐与造影剂体积之间存在显著相关性。在糖尿病患者中,没有发现可以有效减少CIAKI发生的策略。

在接受经皮冠状动脉操作的患者中,相比于生理盐水,他汀类药物与CIAKI风险显著降低相关,并且多个研究结果一致。虽然黄嘌呤、NAC、NaHCO3、NAC+NaHCO3、缺血预处理和钠尿肽可能具有保护作用,但在多个敏感性分析中这些结果并不一致。

原始出处:


Daniele Giacoppo, et al. Preventive Strategies for Contrast-Induced Acute Kidney Injury in Patients Undergoing Percutaneous Coronary Procedures. Circulation: Cardiovascular Interventions. https://doi.org/10.1161/CIRCINTERVENTIONS.116.004383

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    2017-10-03 quxin068
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    2018-01-03 howi
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    2017-11-25 yzh399
  4. 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createdTime=Sat May 13 23:52:02 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197384, encodeId=f5d819e3847b, content=认真学习,把间接经验应用到临床实践中去,然后再总结出新思路。点赞啦!, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat May 13 07:04:12 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397183, encodeId=eba2139e183ea, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, 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time=2017-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=196492, encodeId=ea50196492a5, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28761705280, createdName=cuiyejia, createdTime=Thu May 11 07:27:08 CST 2017, time=2017-05-11, status=1, ipAttribution=)]
    2017-05-13 1e1263e3m20(暂无匿称)

    学习了,多谢分享

    0

  5. 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createdTime=Sat May 13 23:52:02 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197384, encodeId=f5d819e3847b, content=认真学习,把间接经验应用到临床实践中去,然后再总结出新思路。点赞啦!, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat May 13 07:04:12 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397183, encodeId=eba2139e183ea, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, 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time=2017-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1494027, encodeId=7044149402e02, content=<a href='/topic/show?id=3e34949e333' target=_blank style='color:#2F92EE;'>#造影#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94973, encryptionId=3e34949e333, topicName=造影)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=908d9134595, createdName=sodoo, createdTime=Fri May 12 12:52:00 CST 2017, time=2017-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=196768, encodeId=3b67196e682d, content=之前遇到过一个,肾功能稍差的,需要造影,请了肾内科,就让我们充分水化, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f6522059195, createdName=1781ed7d57m, createdTime=Thu May 11 22:28:55 CST 2017, time=2017-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=196492, encodeId=ea50196492a5, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28761705280, createdName=cuiyejia, createdTime=Thu May 11 07:27:08 CST 2017, time=2017-05-11, status=1, ipAttribution=)]
    2017-05-13 ylzr123

    认真学习,把间接经验应用到临床实践中去,然后再总结出新思路。点赞啦!

    0

  6. 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time=2017-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1494027, encodeId=7044149402e02, content=<a href='/topic/show?id=3e34949e333' target=_blank style='color:#2F92EE;'>#造影#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94973, encryptionId=3e34949e333, topicName=造影)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=908d9134595, createdName=sodoo, createdTime=Fri May 12 12:52:00 CST 2017, time=2017-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=196768, encodeId=3b67196e682d, content=之前遇到过一个,肾功能稍差的,需要造影,请了肾内科,就让我们充分水化, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f6522059195, createdName=1781ed7d57m, createdTime=Thu May 11 22:28:55 CST 2017, time=2017-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=196492, encodeId=ea50196492a5, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28761705280, createdName=cuiyejia, createdTime=Thu May 11 07:27:08 CST 2017, time=2017-05-11, status=1, ipAttribution=)]
  7. 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createdTime=Sat May 13 23:52:02 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197384, encodeId=f5d819e3847b, content=认真学习,把间接经验应用到临床实践中去,然后再总结出新思路。点赞啦!, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat May 13 07:04:12 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397183, encodeId=eba2139e183ea, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Fri May 12 12:52:00 CST 2017, time=2017-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1447149, encodeId=c834144e1494b, content=<a href='/topic/show?id=97e1309105d' target=_blank style='color:#2F92EE;'>#冠状动脉造影#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30910, encryptionId=97e1309105d, topicName=冠状动脉造影)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/RNJfsfhsEic2avjCncr2VWPKViaUUV8QbHGvDicvYf6AiaQxTlhBo1TZBFuZQq80ia2pejj3QwjOy03Hyt1z1b3DQpA/132, createdBy=2e4c5322318, createdName=mhzhuang@stu.e, createdTime=Fri May 12 12:52:00 CST 2017, time=2017-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1494027, encodeId=7044149402e02, content=<a href='/topic/show?id=3e34949e333' target=_blank style='color:#2F92EE;'>#造影#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94973, encryptionId=3e34949e333, topicName=造影)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=908d9134595, createdName=sodoo, createdTime=Fri May 12 12:52:00 CST 2017, time=2017-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=196768, encodeId=3b67196e682d, content=之前遇到过一个,肾功能稍差的,需要造影,请了肾内科,就让我们充分水化, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f6522059195, createdName=1781ed7d57m, createdTime=Thu May 11 22:28:55 CST 2017, time=2017-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=196492, encodeId=ea50196492a5, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28761705280, createdName=cuiyejia, createdTime=Thu May 11 07:27:08 CST 2017, time=2017-05-11, status=1, ipAttribution=)]
  8. 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createdName=howi, createdTime=Wed Jan 03 07:52:00 CST 2018, time=2018-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1814291, encodeId=5e8918142918e, content=<a href='/topic/show?id=54149498e79' target=_blank style='color:#2F92EE;'>#造影术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94987, encryptionId=54149498e79, topicName=造影术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=310e209, createdName=yzh399, createdTime=Sat Nov 25 01:52:00 CST 2017, time=2017-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197698, encodeId=eb4719e698aa, content=学习了,多谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=84e21956153, createdName=1e1263e3m20(暂无匿称), createdTime=Sat May 13 23:52:02 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197384, encodeId=f5d819e3847b, content=认真学习,把间接经验应用到临床实践中去,然后再总结出新思路。点赞啦!, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat May 13 07:04:12 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397183, encodeId=eba2139e183ea, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Fri May 12 12:52:00 CST 2017, time=2017-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1447149, encodeId=c834144e1494b, content=<a href='/topic/show?id=97e1309105d' target=_blank style='color:#2F92EE;'>#冠状动脉造影#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30910, encryptionId=97e1309105d, topicName=冠状动脉造影)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/RNJfsfhsEic2avjCncr2VWPKViaUUV8QbHGvDicvYf6AiaQxTlhBo1TZBFuZQq80ia2pejj3QwjOy03Hyt1z1b3DQpA/132, createdBy=2e4c5322318, createdName=mhzhuang@stu.e, createdTime=Fri May 12 12:52:00 CST 2017, time=2017-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1494027, encodeId=7044149402e02, content=<a href='/topic/show?id=3e34949e333' target=_blank style='color:#2F92EE;'>#造影#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94973, encryptionId=3e34949e333, topicName=造影)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=908d9134595, createdName=sodoo, createdTime=Fri May 12 12:52:00 CST 2017, time=2017-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=196768, encodeId=3b67196e682d, content=之前遇到过一个,肾功能稍差的,需要造影,请了肾内科,就让我们充分水化, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f6522059195, createdName=1781ed7d57m, createdTime=Thu May 11 22:28:55 CST 2017, time=2017-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=196492, encodeId=ea50196492a5, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28761705280, createdName=cuiyejia, createdTime=Thu May 11 07:27:08 CST 2017, time=2017-05-11, status=1, ipAttribution=)]
    2017-05-12 sodoo
  9. 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createdTime=Sat May 13 23:52:02 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197384, encodeId=f5d819e3847b, content=认真学习,把间接经验应用到临床实践中去,然后再总结出新思路。点赞啦!, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat May 13 07:04:12 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397183, encodeId=eba2139e183ea, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, 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time=2017-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1494027, encodeId=7044149402e02, content=<a href='/topic/show?id=3e34949e333' target=_blank style='color:#2F92EE;'>#造影#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94973, encryptionId=3e34949e333, topicName=造影)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=908d9134595, createdName=sodoo, createdTime=Fri May 12 12:52:00 CST 2017, time=2017-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=196768, encodeId=3b67196e682d, content=之前遇到过一个,肾功能稍差的,需要造影,请了肾内科,就让我们充分水化, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f6522059195, createdName=1781ed7d57m, createdTime=Thu May 11 22:28:55 CST 2017, time=2017-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=196492, encodeId=ea50196492a5, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28761705280, createdName=cuiyejia, createdTime=Thu May 11 07:27:08 CST 2017, time=2017-05-11, status=1, ipAttribution=)]
    2017-05-11 1781ed7d57m

    之前遇到过一个,肾功能稍差的,需要造影,请了肾内科,就让我们充分水化

    0

  10. 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createdTime=Sat May 13 23:52:02 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197384, encodeId=f5d819e3847b, content=认真学习,把间接经验应用到临床实践中去,然后再总结出新思路。点赞啦!, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat May 13 07:04:12 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397183, encodeId=eba2139e183ea, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Fri May 12 12:52:00 CST 2017, time=2017-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1447149, encodeId=c834144e1494b, content=<a href='/topic/show?id=97e1309105d' target=_blank style='color:#2F92EE;'>#冠状动脉造影#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30910, encryptionId=97e1309105d, topicName=冠状动脉造影)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/RNJfsfhsEic2avjCncr2VWPKViaUUV8QbHGvDicvYf6AiaQxTlhBo1TZBFuZQq80ia2pejj3QwjOy03Hyt1z1b3DQpA/132, createdBy=2e4c5322318, createdName=mhzhuang@stu.e, createdTime=Fri May 12 12:52:00 CST 2017, time=2017-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1494027, encodeId=7044149402e02, content=<a href='/topic/show?id=3e34949e333' target=_blank style='color:#2F92EE;'>#造影#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94973, encryptionId=3e34949e333, topicName=造影)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=908d9134595, createdName=sodoo, createdTime=Fri May 12 12:52:00 CST 2017, time=2017-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=196768, encodeId=3b67196e682d, content=之前遇到过一个,肾功能稍差的,需要造影,请了肾内科,就让我们充分水化, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f6522059195, createdName=1781ed7d57m, createdTime=Thu May 11 22:28:55 CST 2017, time=2017-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=196492, encodeId=ea50196492a5, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28761705280, createdName=cuiyejia, createdTime=Thu May 11 07:27:08 CST 2017, time=2017-05-11, status=1, ipAttribution=)]
    2017-05-11 cuiyejia

    学习了,谢谢

    0