Arthritis Care Res:狼疮增加自发性蛛网膜下腔出血的风险

2017-07-21 zhuliee 来宝网

据Arthritis Care & Research.四月发行的报道称,患有系统性红斑狼疮的患者发生自发性蛛网膜下腔出血(SAH)的风险增加,且SAH患病后的死亡率增加。



SLE患者SAH的发生率升高】据Arthritis Care & Research.四月发行的报道称,患有系统性红斑狼疮的患者发生自发性蛛网膜下腔出血(SAH)的风险增加,且SAH患病后的死亡率增加。

来自台湾台北双豪医院Yu-Sheng Chang及他的同事进行了一项全国性的基于人群的研究,以评估SLE患者患SAH的危险性。该研究比较了16,967例来自台湾国民健康保险数据库的SLE患者和16,967 随机选择的年龄和性别匹配的未患SLE的人自发性蛛网膜下腔出血的发生率。

研究者发现,SLE患者组自发性蛛网膜下腔出血的发生率显着升高。(发病率,4.84)相比于无SLE的自发性蛛网膜下腔出血的患者,患有SLE的患者发生自发性蛛网膜下腔出血后的死亡率显着升高,即使是在年轻患者中(60% vs 38.9%)。新发自发性蛛网膜下腔出血的独立危险因素包括年龄(危险比[ HR ],1.03);输注血小板(危险比2.75);红细胞输注(危险比7.11)和平均每日激素剂量大于或等于10毫克(危险比4.36)。

该作者说:“总之,在全国人口数据集的基础上,我们的研究首先发现了SLE患者自发性蛛网膜下腔出血的发生率升高。”“年龄大的SLE患者,每日接受的激素剂量过高,或者曾经有血小板或者红细胞输注史的SLE患者发生自发性蛛网膜下腔出血危险性更高。”

原始出处:

Yu-Sheng Chang, Chia-Jen Liu, Wei-Sheng Chen, et al. Increased Risk of Subarachnoid Hemorrhage in Patients With Systemic Lupus Erythematosus: A Nationwide Population-Based Study. Arthritis Care & Research, 2017. DOI: 10.1002/acr.21846.

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    2018-03-09 spake

    对于狼疮重症患者怎么判断是否有蛛网膜下出血呢

    0

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    2017-07-23 zhaojie88
  6. 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time=2017-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=225125, encodeId=b034225125b9, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Sat Jul 22 17:37:08 CST 2017, time=2017-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=224743, encodeId=d3d6224e43f0, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Fri Jul 21 20:35:54 CST 2017, time=2017-07-21, status=1, ipAttribution=)]
    2017-07-23 sodoo
  8. 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    2017-07-22 三生有幸9135

    学习一下谢谢分享

    0

  9. 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time=2017-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=225125, encodeId=b034225125b9, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Sat Jul 22 17:37:08 CST 2017, time=2017-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=224743, encodeId=d3d6224e43f0, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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    2017-07-21 changjiu

    学习了,谢谢

    0

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