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Eur J Neurosci：Müller神经胶质细胞在视网膜发育和疾病中的作用

2018-06-11 cuiguizhong MedSci原创

Müller神经胶质细胞视网膜疾病视网膜发育
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美国马里兰州约翰霍普金斯医学院眼科的Subirada PV近日在Eur J Neurosci发表了一篇综述，对Müller神经胶质细胞的生理功能进行了系统性阐述，并对其MGC在糖尿病视网膜炎症、胶质增生、营养和抗氧化因子的合成及分泌中的作用进行了讨论。

美国马里兰州约翰霍普金斯医学院眼科的Subirada PV近日在Eur J Neurosci发表了一篇综述，对Müller神经胶质细胞的生理功能进行了系统性阐述，并对其MGC在糖尿病视网膜炎症、胶质增生、营养和抗氧化因子的合成及分泌中的作用进行了讨论。

已知Müller神经胶质细胞（MGCs）会积极参与视网膜发育，并通过多种细胞内机制维持体内平衡。由于在其他神经元组织中没有同源细胞，所以可以肯定MGC对视网膜的健康状态至关重要。这些大胶质细胞位于柱状亚基的中心，并具有与神经元、星形胶质细胞、小胶质细胞和内皮细胞相互作用、调节不同生物学事件的能力。有几项研究将注意力集中在MGC在糖尿病视网膜病变中的作用。糖尿病视网膜病变是多种损害同时存在的渐进形式。正如预期的那样，数据表明，MGC根据刺激的不同程度做出不同的反应。因此，MGC会在整个疾病过程中引发不同的生物学事件。

在这篇文章中，他们描述了MGCs的生理功能，及其MGC在糖尿病视网膜炎症、胶质增生、营养和抗氧化因子的合成及分泌中的作用。同时，在文章中，作者提出，应当考虑MGC在疾病早期的保护性作用和晚期的有害作用。鉴于研究结果，他们讨论并提出了一个问题：单个细胞类型的调节是否可能改善甚至重建视网膜损伤后的视网膜功能？

原文出处：

Subirada， P.V.， et al.， A journey into the retina： Muller Glia commanding survival and death. Eur J Neurosci， 2018.

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    2019-02-23 ZGMFX24A

    #神经胶质细胞#

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    2018-06-13 zutt

    #视网膜#

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    2018-06-13 neurowu

    #发育#

    0

  4. 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topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Wed Jun 13 14:53:00 CST 2018, time=2018-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1389197, encodeId=f6a4138919efa, content=<a href='/topic/show?id=acf3840e459' target=_blank style='color:#2F92EE;'>#胶质细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84074, encryptionId=acf3840e459, topicName=胶质细胞)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/DC48AC6B5FFD609EED5594C15A97B420/100, createdBy=57dc2500034, createdName=ms1692212821629096, createdTime=Wed Jun 13 14:53:00 CST 2018, time=2018-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323527, encodeId=9c7e32352e4e, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, 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    2018-06-13 lsndxfj

    #ROS#

    0

  5. 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    2018-06-13 ms1692212821629096

    #胶质细胞#

    0

  6. 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    2018-06-12 龙胆草

    学习谢谢分享

    0

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content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Tue Jun 12 08:47:30 CST 2018, time=2018-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323481, encodeId=28e4323481f8, content=学习了感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/C20CB8E4EBB36F5B821651C710BCB491/100, createdBy=18de1715848, createdName=lofter, createdTime=Tue Jun 12 06:55:43 CST 2018, time=2018-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323453, encodeId=8f20323453fc, content=学了, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKcmgibQ4oCrK7Z6f4CvMcs4k7QUGCkhopcGxvxaBfVciadECSIwaRVttllIOEKumpEaRrq5PoOUxow/0, createdBy=e3bb2081203, createdName=哈哈869, createdTime=Tue Jun 12 06:23:06 CST 2018, time=2018-06-12, status=1, ipAttribution=)]
    2018-06-12 神功盖世

    阅

    0

  8. 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    2018-06-12 明月清辉

    谢谢分享.学习了

    0

  9. 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    2018-06-12 lofter

    学习了感谢分享

    0

  10. 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    2018-06-12 哈哈869

    学了

    0

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