J Am Coll Cardiol:2型糖尿病患者心衰的患病率和发病率

2018-04-20 吴星 环球医学

2018年2月,发表在《J Am Coll Cardiol》的一项由美国和英国科学家进行的研究考察了2型糖尿病患者心血管结局试验中的心衰(HF)患病率和发病率。

2018年2月,发表在《J Am Coll Cardiol》的一项由美国和英国科学家进行的研究考察了2型糖尿病患者心血管结局试验中的心衰(HF)患病率和发病率。

尽管已有多个降糖治疗影响HF风险的例子,但是这些药物的心血管结局试验中HF的明确数据还没有被系统地描述。

在本系统评价中,研究者纳入了2017年6月之前发表的评估降糖治疗的大型(n>1000)III期和IV期心血管结局试验。数据来自于发表的文献、美国食品药品监督管理局(FDA)咨询委员会记录、FDA说明书文档。

总体来说,评估了包括152737例患者的21项试验。基线HF和HF发病的定义和发生率不一致。3项研究提供了基线射血分数数据,但是并非特定于HF患者。无试验报道HF确诊时的功能分级、射血分数或HF治疗。15项试验具有HF住院数据,但是仅有2项在首要复合终点中纳入了HF相关事件。本系统评价强调了降糖治疗的心血管结局试验中HF数据采集的差距,并列出了改善HF特征的理论基础和策略。

原始出处:

Greene SJ, Vaduganathan M, Khan MS, et al. Prevalent and Incident Heart Failure in Cardiovascular Outcome Trials of Patients With Type 2 Diabetes. J Am Coll Cardiol. 2018 Mar 27;71(12):1379-1390. doi: 10.1016/j.jacc.2018.01.047. Epub 2018 Mar 10.

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    2019-01-13 waiwai3030
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    2018-04-22 xinmeili
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