Lancet Respir Med:流感下呼吸道感染 危害知多少

2019-02-21 王淳 环球医学

2019年1月,《Lancet Respir Med》上发表的2017全球疾病负担研究(GBD)的一项分析,考察了2017年流感下呼吸道感染(LRTI)造成的死亡率、发病率和住院。

2019年1月,《Lancet Respir Med》上发表的2017全球疾病负担研究(GBD)的一项分析,考察了2017年流感下呼吸道感染(LRTI)造成的死亡率、发病率和住院。

背景:虽然流感负担常在历史流行病学的背景下和未来流行病学下讨论,但每年LRTI和其他呼吸疾病(如慢性阻塞性肺病)严重负担都可归因于季节性流感。GBD 2017是量化与综合性疾病和残疾相关的健康损失的系统性科研工作。本文关注的是归因于流感的LRIT。

方法:作为GBD 2017一部分,研究者通过年龄和1990~2017年的年份,建模了每个国家和选定的次国家地区的归因于流感的LRTI发病率、住院率和死亡率。研究者使用反事实方法首次评估了LRTI发病率、住院率和死亡率,然后将这些结局中的一部分归因于流感。

结果:2017年,所有年龄死亡事件中流感LRTI占到了约145000例(95%不确定区间[UI],99000~200000)。流感LRTI死亡率在70岁以上人群中最高(16.4例/100000(95% UI,11.6~21.9)),所有年龄中,死亡率最高的为东欧(5.2/100000[95% UI,3.5~7.2])。研究者估计,因LRTI造成的住院中流感LRTI占到了9459000例(95% UI,3709000~22935000)和81536000住院日(24330000~259851000)。研究者估计,11.5%(95% UI,10.0~12.9)的LRTI发作归因于流感,相当于54481000(38465000~73864000)次发作和8172000次严重发作(5000000~13296000)。

解释:这项流感LRTI负担的综合评估表明,流感每年对全球健康造成巨大影响。虽然预防流感计划在流行病学上非常重要,但因季节性流感LRTI造成的健康损失不能忽视,并应考虑使用疫苗。需要改善流感预防措施的努力。

原始出处:

GBD 2017 Influenza Collaborators. Mortality, morbidity, and hospitalisations due to influenza lower respiratory tract infections, 2017: an analysis for the Global Burden of Disease Study 2017. Lancet Respir Med. 2019 Jan;7(1):69-89. doi: 10.1016/S2213-2600(18)30496-X. Epub 2018 Dec 12.

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    2020-01-13 howi
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    2019-02-23 吴教授

    学习了,学习了

    0

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    2019-02-23 zhmscau
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