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JCEM：X连锁性低磷血症的患病率和死亡率

2019-11-16 xing.T MedSci原创

X连锁性低磷血症患病率死亡率
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由此可见，该研究保守估计了英国儿童和成人中XLH的患病率。这些患者死亡率出乎意料地增加，可能与其他FGF23相关的疾病有关。

X连锁性低磷酸盐血症（XLH）是一种罕见的多系统性疾病，具有明显的肌肉骨骼表型。近日，内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章，研究人员旨在增进人们对整个生命过程中XLH患病率和整体生存率的了解。

这是一项基于人群的队列研究，研究人员使用了英国（UK）1995-2016年期间的大型初级保健数据库。XLH病例按年龄、性别和治疗进行了匹配，最多匹配四个对照者。研究人员估计了研究期间的患病率趋势（按年龄分层），并将病例之间的存活率与对照组进行比较。

在522例潜在病例中，至少有122例（23.4％）被诊断为XLH，而62例（11.9％）被分类为极有可能（保守定义）。在主要分析中，患病率（95％CI）从1995-1999年的百万分之3.1（1.5-6.7）增加到2012-2016年的百万分之14.0（10.8-18.1）。使用保守定义相应的估计值为3.0（1.4-6.5）到8.1（5.8-11.4）。随访期间有9例（7.4％）死亡，中位年龄为64岁。对照组中有14人（2.9％）死亡，年龄中位数为72.5岁。与对照组相比，可能患有XLH的个体死亡率显著增加（风险比[HR]为2.93，95％CI为1.24-6.91）。同样，在那些可能或非常可能患有XLH的人群中（HR为6.65，1.44-30.72）。

由此可见，该研究保守估计了英国儿童和成人中XLH的患病率。这些患者死亡率出乎意料地增加，可能与其他FGF23相关的疾病有关。 

原始出处：

Samuel Hawley,et al.Prevalence and mortality of individuals with X-linked hypophosphataemia: a United Kingdom real world data analysis.J Clin Endocrinol Metab.2019.https://doi.org/10.1210/clinem/dgz203

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    2020-07-11 12498ebem27暂无昵称

    #X连锁#

    0

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    2020-01-19 achengzhao

    #JCE#

    0

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    2020-01-20 hmwwww

    #X连锁性低磷血症#

    0

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    2020-04-29 smallant2015

    #JCEM#

    0

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    2019-11-18 xinmeili

    #患病率#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1665435, encodeId=5161166543543, content=<a href='/topic/show?id=f6fd1891e53' target=_blank style='color:#2F92EE;'>#X连锁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18917, encryptionId=f6fd1891e53, topicName=X连锁)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bdb025960146, createdName=12498ebem27暂无昵称, createdTime=Sat Jul 11 02:26:00 CST 2020, time=2020-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063286, encodeId=430520632865d, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Sun Jan 19 23:26:00 CST 2020, time=2020-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2036552, encodeId=a841203655255, content=<a href='/topic/show?id=d50b1892341' target=_blank style='color:#2F92EE;'>#X连锁性低磷血症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18923, encryptionId=d50b1892341, topicName=X连锁性低磷血症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Mon Jan 20 00:26:00 CST 2020, time=2020-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1777904, encodeId=1acf1e7790498, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Wed Apr 29 12:26:00 CST 2020, time=2020-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1250649, encodeId=f2541250649c9, content=<a href='/topic/show?id=7d6f52988e1' target=_blank style='color:#2F92EE;'>#患病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52988, encryptionId=7d6f52988e1, topicName=患病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Mon Nov 18 06:26:00 CST 2019, time=2019-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1531009, encodeId=9de615310091a, content=<a href='/topic/show?id=e80b26301b6' target=_blank style='color:#2F92EE;'>#低磷血症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26301, encryptionId=e80b26301b6, topicName=低磷血症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7f312187038, createdName=medscijoin, createdTime=Mon Nov 18 06:26:00 CST 2019, time=2019-11-18, status=1, ipAttribution=)]
    2019-11-18 medscijoin

    #低磷血症#

    0