Ann Rheum Dis:肥胖与类风湿关节炎临床缓解和低MRI炎症的几率

2017-06-19 xiangting MedSci原创

与非肥胖患者相比,肥胖RA患者的DAS28缓解率较低,但低MRI活动性的几率相似,表明肥胖及其相关并发症可能会使临床疾病活动度评估有所偏倚。

肥胖被认为是难治性类风湿性关节炎(RA)的危险因素。这项研究评估了肥胖对达到临床和影像学定义的疾病活动性低的影响。这项研究评估了来自GO-BEFORE和GO-FORWARD随机临床试验的470例RA患者。入组患者分别在基线、24周和52周接受了盲法临床活动度评估和MRI。使用RA MRI评分系统确定滑膜炎,骨炎和总炎症评分。使用多变量logistic回归分析比较肥胖和非肥胖患者24周时使用28关节和C反应蛋白(DAS28-CRP)缓解、成分测量或低MRI炎症测量的疾病活动评分的几率。24周时,肥胖患者实现DAS28(CRP)缓解(OR 0.47; 95%CI 0.24-0.92,p = 0.03)的可能性明显降低。与正常体重患者相比,肥胖患者低滑膜炎(OR 0.94; 95%CI 0.51至1.72,p = 0.84)和炎症评分(OR 1.16; 95%CI 0.61至2.22,p = 0.64)的几率相似,获得低骨炎评分(OR 2.06; 95%CI 1.10至3.84,p = 0.02)的几率更高。与非肥胖患者相比,肥胖RA患者的DAS28缓解率较低,但低MRI活动性的几率相似,表

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    2017-06-21 lmm397
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    2017-06-19 flysky120

    学习一下知识了

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