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FEBS Lett：铜绿假单胞菌鼠李糖脂与帕金森病相关蛋白α-突触核蛋白之间的关系

2018-04-01 MedSci MedSci原创

关注

帕金森病相关蛋白α-突触核蛋白（αSN）是一种天然的非折叠蛋白，但其结构可以通过膜和表面活性剂来调节。机会性病原体铜绿假单胞菌（PA）产生并分泌调节细菌生物膜的生物表面活性剂鼠李糖脂（RL）。 本研究中，研究人员发现单体RL增强了αSN透化膜的能力，而胶束RL迅速诱导具有蠕虫状原纤维外观的蛋白质β-折叠结构，这种结构不能接种无RL的神经元，而是比αSN原纤化更快地转变成线性原纤维。暴露于αSN会降

帕金森病相关蛋白α-突触核蛋白（αSN）是一种天然的非折叠蛋白，但其结构可以通过膜和表面活性剂来调节。机会性病原体铜绿假单胞菌（PA）产生并分泌调节细菌生物膜的生物表面活性剂鼠李糖脂（RL）。

本研究中，研究人员发现单体RL增强了αSN透化膜的能力，而胶束RL迅速诱导具有蠕虫状原纤维外观的蛋白质β-折叠结构，这种结构不能接种无RL的神经元，而是比αSN原纤化更快地转变成线性原纤维。暴露于αSN会降低PA的生物膜形成程度，除非RL存在。

该研究结果表明，RL与αSN的相互作用可能影响αSN聚集和细胞毒性，可能牵涉微生物代谢物在帕金森病的发生和进展中。

原始出处：

Andersen KK, Vad BS, et al., Pseudomonas aeruginosa rhamnolipid induces fibrillation of human α-synuclein and modulates its effect on biofilm formation. FEBS Lett. 2018 Mar 23. doi: 1 0.1002/1873-3468.13038.  

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    2018-04-24 循证小兵

    #核蛋白#

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    2018-04-03 ms691033630344116

    #突触#

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    2018-04-03 医者仁心

    #α-突触核蛋白#

    0

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    2018-04-03 三生有幸9135

    学习一下谢谢分享

    0

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    2018-04-01 清风拂面

    谢谢分享学习

    0