Heart:心尖肥厚型心肌病患者心腔闭塞预后不佳

2016-03-13 QQduhp 译 MedSci原创

目的心尖肥厚型心肌病(HCM)患者出现心房纤颤(AF)、卒中、心力衰竭(HF)和死亡的风险增加。该研究的目的在于探究左心室(LV)顶端闭塞是否对HCM患者的病情发展和预后有不利影响。 方法188名患有心尖肥厚型心肌病的患者(114名为男性,平均年龄为67岁)参与研究,研究人员于2008年1月-2010年12月开展了回顾性研究。 心尖闭塞率依据心室舒张末期心尖厚度而定,心腔闭塞率依据心室收缩末期心腔

目的:心尖肥厚型心肌病(HCM)患者出现心房纤颤(AF)、卒中、心力衰竭(HF)和死亡的风险增加。该研究的目的在于探究左心室(LV)顶端闭塞是否对HCM患者的病情发展和预后有不利影响。 


方法:188名患有心尖肥厚型心肌病的患者(114名为男性,平均年龄为67岁)参与研究,研究人员于2008年1月-2010年12月开展了回顾性研究。心尖闭塞率依据心室舒张末期心尖厚度而定,心腔闭塞率依据心室收缩末期心腔高度而定。研究人员关注的主要结果是房颤、卒中、心力衰竭、心血管疾病死亡率的发生率。

结果:在4.4年的随访期间共发生了43例主要结果事件(19例房颤、11例心力衰竭、9例卒中、4例死亡),发生主要结果事件的患者均年迈、左心室容积指数(LAVI)较大、左心室舒张压较大、舒张晚期二尖瓣环组织多普勒流速较小。他们心尖肥厚和闭塞较为明显,心室收缩末期心腔高度较低,心尖闭塞率和心腔闭塞率更高。心尖闭塞率和心腔闭塞率较高的前1/3患者发生不良结果的发生率更高,占54%。年龄、 E/e′、a′、LAVI、心尖厚度、心尖闭塞率和心腔闭塞率等与不良结果发生率明显相关。在多变量分析中,心腔闭塞率仍然是一个重要的预测指标。

结论:研究人员认为,心腔闭塞率是预测HCM不良事件发生率的有效指标。

原始出处:

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    2017-02-08 okhuali
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    2016-03-24 1ddc978cm67(暂无匿称)

    谢谢分享。

    0

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    2016-03-22 1de304d2m86(暂无匿称)

    学习了,了解了

    0

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    2016-03-14 zhaojie88
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    2016-03-14 slcumt
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