J Clin Gastro: 结肠镜腺瘤筛检率需对50岁以下的成年人进行调整

2018-09-02 MedSci MedSci原创

虽然与50岁及以上的筛查成年人相比,年轻人的腺瘤患病率较低,但对年轻人的目标腺瘤检出率(ADR)并没有因此作出调整。在此,研究人员基于筛查结肠镜检查结果估计了50岁以下成人的不同目标ADR。

背景:
虽然与50岁及以上的筛查成年人相比,年轻人的腺瘤患病率较低,但对年轻人的目标腺瘤检出率(ADR)并没有因此作出调整。在此,研究人员基于筛查结肠镜检查结果估计了50岁以下成人的不同目标ADR。

方法:
研究人员在2006年2月至2012年3月期间在韩国的12个内镜检查中心招募了无症状,50岁以下成人进行结肠镜检查。筛查结肠镜检查分为低或高ADR组,ADR低水平组为20%,高水平组为25%。

结果:
来自12个内镜检查中心的5272名接受筛查结肠镜检查的年轻成人的结肠镜筛查腺瘤检出率范围为12.1%至43.8%(中位ADR,24.1%)。当使用20%作为ADR目标水平时,低ADR组的异时性腺瘤和晚期腺瘤的风险显着高于高ADR组(35.4%VS25.7%,P?<0.001; 8.3%VS3.7%,P=0.001)。然而,根据筛查结肠镜检查,使用25%的ADR水平作为目标水平时,年轻成人的高和低ADR组的异时性瘤形成的风险相似。

结论:
年轻人和老年人群之间的最佳目标ADR是不同的,采用20%目标ADR可作为年轻人群的筛查指标。

原始出处:
Yoon, Jin Young et al. An Adjusted Level of Adenoma Detection Rate is Necessary for Adults Below 50 Years Old. Journal of Clinical Gastroenterology. 2018.

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    2019-07-06 许安
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    2018-09-04 zhouqu_8