Am J Gastroenterol:阑尾炎以及阑尾炎手术与溃疡性结肠炎切除风险

2017-06-28 zhangfan MedSci原创

青少年期间或溃疡性结肠炎确诊前的阑尾切除手术不易导致后续的结肠疾病;溃疡性结肠炎确诊后的阑尾炎会加重结肠炎病情

溃疡性结肠炎(UC)是一种慢性炎症性疾病通常使用消炎药治疗,但是很多重症患者仍然需要结肠切除术获得较好的疾病控制效果。研究发现阑尾切除术后,患者具有较低的风险发展为溃疡性结肠炎。 近日研究人员对于阑尾炎,阑尾切除术与溃疡性结肠炎病程之间的关系进行评估。

研究人员对于瑞典国家病人登记数据库中1964-2010溃疡性结肠炎患者资料进行分析获取患者结肠炎确诊前后相关的阑尾炎或阑尾炎手术情况资料以评估阑尾炎与溃疡性结肠炎之间的关系。

研究共包含63711名溃疡性结肠炎患者,其中阑尾切除术2143例,结肠切除术7690例。研究发现,20岁之前接受阑尾切除术以及UC确诊前的阑尾炎患者其结肠切除术风险(HR 0.44,0.27-0.72; HR 0.62, 0.43-0.90)以及溃疡性结肠炎相关事件的住院率(RR0.68, 95%,CI0.64-0.73 ;IRR 0.54, 0.47-0.63)较低。确诊UC后的阑尾切除术导致其结肠切除术风险提高 (HR 1.56, 1.20-2.03), 没有发现存在上述关联的其他病理学(HR 1.40, 0.79-2.47)。

青少年期间或溃疡性结肠炎确诊前的阑尾切除手术不易导致后续的结肠疾病;溃疡性结肠炎确诊后的阑尾炎会加重结肠炎病情。

原始出处:


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    2017-08-04 许安
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    2018-04-11 nymo
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    2017-07-01 方舒

    学习

    0

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