Radiology:复发胶质母细胞瘤动态对比增强MRI指标变异来源于哪里?

2019-06-05 shaosai MedSci原创

本研究旨在评价不同阅片者对胶质母细胞瘤患者行动态增强(DCE)MRI征象判读差异性(IRV)因素。

本研究旨在评价不同阅片者对胶质母细胞瘤患者行动态增强(DCE)MRI征象判读差异性(IRV)因素。

本研究共纳入了18例患者并行DCE MRI检查的患者。78个影像学检查进行分析血浆与组织血管外、细胞外空间钆剂转移常数(Ktrans)、细胞外血管外空间(ve)部分容积、和最初钆剂浓度曲线下面积(IAUGC)。由两个接受训练的团队对增强肿瘤进行分割。经分割配对后提取增强肿瘤的平均和中位数参数值。利用ICC和线性混合模型研究相对治疗成像时机、图谱质量、扫描设备和序列、平均肿瘤体积和肿瘤体积在阅片者间的变异对IRV的影响。

结果为,对平均和中位数IAUGC、平均和中位数Ktrans,和中位数ve  ,的平均阅片者变异分别为18% ± 24, 17% ± 23, 27% ± 34, 16% ± 27, 27% ± 34。治疗前和治疗后以上指标的ICC范围分别为0.90-1.0、0.48-0.76。阅片者所测肿瘤体积变异是与IRV有显着相关性。

本研究表明,不同阅片者对肿瘤分割的差异性是动态增强MRI参数变异的主要来源。

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