赛诺菲放弃与Merrimack合作研发抗癌药物

2014-06-23 佚名 不详

众所周知,抗癌药物的研发工作面临着极高的失败率,这一点连世界各大医药巨头都无法幸免。赛诺菲最近就宣布由于连续遇到失败,赛诺菲公司已经放弃与其合作伙伴Merrimack公司合作研究抗癌药物MM-121。MM121是一种阻断ErbB3受体的抗体类药物,ErbB3受体与肿瘤生长有直接关系。2009年赛诺菲公司与Merrimack公司签订总价值约4亿7千万美元的协议共同研究MM-121在乳腺癌、宫颈癌

众所周知,抗癌药物的研发工作面临着极高的失败率,这一点连世界各大医药巨头都无法幸免。赛诺菲最近就宣布由于连续遇到失败,赛诺菲公司已经放弃与其合作伙伴Merrimack公司合作研究抗癌药物MM-121。MM121是一种阻断ErbB3受体的抗体类药物,ErbB3受体与肿瘤生长有直接关系。2009年赛诺菲公司与Merrimack公司签订总价值约4亿7千万美元的协议共同研究MM-121在乳腺癌、宫颈癌和肺癌等领域的应用。

但随后几年MM121连续三次在临床研究中遭受挫折,并最终使赛诺菲公司失去耐性。尽管如此,Merrimack公司仍然对MM121充满信心,公司计划将对现有的临床二期研究数据进行归纳分析以便制定下一步研究计划.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1995901, encodeId=fc111995901d6, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Sun Mar 15 04:26:00 CST 2015, time=2015-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1703572, encodeId=a1581e035729a, content=<a href='/topic/show?id=0d2869594b' target=_blank style='color:#2F92EE;'>#ERR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6959, encryptionId=0d2869594b, topicName=ERR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a72d30527892, createdName=surilei, createdTime=Sat Mar 21 22:26:00 CST 2015, time=2015-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1299799, encodeId=0cf41299e9997, content=<a href='/topic/show?id=ed5ee332423' target=_blank style='color:#2F92EE;'>#研发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73324, encryptionId=ed5ee332423, topicName=研发)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aea0290, createdName=lqvr, createdTime=Wed Jun 25 06:26:00 CST 2014, time=2014-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308199, encodeId=dbd9130819938, content=<a href='/topic/show?id=6e495554550' target=_blank style='color:#2F92EE;'>#抗癌药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55545, encryptionId=6e495554550, topicName=抗癌药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fe6351, createdName=flyingeagle77, createdTime=Wed Jun 25 06:26:00 CST 2014, time=2014-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1314606, encodeId=4365131460641, content=<a href='/topic/show?id=9d4b5554131' target=_blank style='color:#2F92EE;'>#抗癌药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55541, encryptionId=9d4b5554131, topicName=抗癌药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Jun 25 06:26:00 CST 2014, time=2014-06-25, status=1, ipAttribution=)]
    2015-03-15 yb6560
  2. [GetPortalCommentsPageByObjectIdResponse(id=1995901, encodeId=fc111995901d6, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Sun Mar 15 04:26:00 CST 2015, time=2015-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1703572, encodeId=a1581e035729a, content=<a href='/topic/show?id=0d2869594b' target=_blank style='color:#2F92EE;'>#ERR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6959, encryptionId=0d2869594b, topicName=ERR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a72d30527892, createdName=surilei, createdTime=Sat Mar 21 22:26:00 CST 2015, time=2015-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1299799, encodeId=0cf41299e9997, content=<a href='/topic/show?id=ed5ee332423' target=_blank style='color:#2F92EE;'>#研发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73324, encryptionId=ed5ee332423, topicName=研发)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aea0290, createdName=lqvr, createdTime=Wed Jun 25 06:26:00 CST 2014, time=2014-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308199, encodeId=dbd9130819938, content=<a href='/topic/show?id=6e495554550' target=_blank style='color:#2F92EE;'>#抗癌药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55545, encryptionId=6e495554550, topicName=抗癌药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fe6351, createdName=flyingeagle77, createdTime=Wed Jun 25 06:26:00 CST 2014, time=2014-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1314606, encodeId=4365131460641, content=<a href='/topic/show?id=9d4b5554131' target=_blank style='color:#2F92EE;'>#抗癌药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55541, encryptionId=9d4b5554131, topicName=抗癌药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Jun 25 06:26:00 CST 2014, time=2014-06-25, status=1, ipAttribution=)]
    2015-03-21 surilei
  3. [GetPortalCommentsPageByObjectIdResponse(id=1995901, encodeId=fc111995901d6, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Sun Mar 15 04:26:00 CST 2015, time=2015-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1703572, encodeId=a1581e035729a, content=<a href='/topic/show?id=0d2869594b' target=_blank style='color:#2F92EE;'>#ERR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6959, encryptionId=0d2869594b, topicName=ERR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a72d30527892, createdName=surilei, createdTime=Sat Mar 21 22:26:00 CST 2015, time=2015-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1299799, encodeId=0cf41299e9997, content=<a href='/topic/show?id=ed5ee332423' target=_blank style='color:#2F92EE;'>#研发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73324, encryptionId=ed5ee332423, topicName=研发)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aea0290, createdName=lqvr, createdTime=Wed Jun 25 06:26:00 CST 2014, time=2014-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308199, encodeId=dbd9130819938, content=<a href='/topic/show?id=6e495554550' target=_blank style='color:#2F92EE;'>#抗癌药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55545, encryptionId=6e495554550, topicName=抗癌药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fe6351, createdName=flyingeagle77, createdTime=Wed Jun 25 06:26:00 CST 2014, time=2014-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1314606, encodeId=4365131460641, content=<a href='/topic/show?id=9d4b5554131' target=_blank style='color:#2F92EE;'>#抗癌药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55541, encryptionId=9d4b5554131, topicName=抗癌药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Jun 25 06:26:00 CST 2014, time=2014-06-25, status=1, ipAttribution=)]
    2014-06-25 lqvr
  4. [GetPortalCommentsPageByObjectIdResponse(id=1995901, encodeId=fc111995901d6, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Sun Mar 15 04:26:00 CST 2015, time=2015-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1703572, encodeId=a1581e035729a, content=<a href='/topic/show?id=0d2869594b' target=_blank style='color:#2F92EE;'>#ERR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6959, encryptionId=0d2869594b, topicName=ERR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a72d30527892, createdName=surilei, createdTime=Sat Mar 21 22:26:00 CST 2015, time=2015-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1299799, encodeId=0cf41299e9997, content=<a href='/topic/show?id=ed5ee332423' target=_blank style='color:#2F92EE;'>#研发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73324, encryptionId=ed5ee332423, topicName=研发)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aea0290, createdName=lqvr, createdTime=Wed Jun 25 06:26:00 CST 2014, time=2014-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308199, encodeId=dbd9130819938, content=<a href='/topic/show?id=6e495554550' target=_blank style='color:#2F92EE;'>#抗癌药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55545, encryptionId=6e495554550, topicName=抗癌药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fe6351, createdName=flyingeagle77, createdTime=Wed Jun 25 06:26:00 CST 2014, time=2014-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1314606, encodeId=4365131460641, content=<a href='/topic/show?id=9d4b5554131' target=_blank style='color:#2F92EE;'>#抗癌药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55541, encryptionId=9d4b5554131, topicName=抗癌药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Jun 25 06:26:00 CST 2014, time=2014-06-25, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1995901, encodeId=fc111995901d6, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Sun Mar 15 04:26:00 CST 2015, time=2015-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1703572, encodeId=a1581e035729a, content=<a href='/topic/show?id=0d2869594b' target=_blank style='color:#2F92EE;'>#ERR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6959, encryptionId=0d2869594b, topicName=ERR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a72d30527892, createdName=surilei, createdTime=Sat Mar 21 22:26:00 CST 2015, time=2015-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1299799, encodeId=0cf41299e9997, content=<a href='/topic/show?id=ed5ee332423' target=_blank style='color:#2F92EE;'>#研发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73324, encryptionId=ed5ee332423, topicName=研发)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aea0290, createdName=lqvr, createdTime=Wed Jun 25 06:26:00 CST 2014, time=2014-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308199, encodeId=dbd9130819938, content=<a href='/topic/show?id=6e495554550' target=_blank style='color:#2F92EE;'>#抗癌药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55545, encryptionId=6e495554550, topicName=抗癌药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fe6351, createdName=flyingeagle77, createdTime=Wed Jun 25 06:26:00 CST 2014, time=2014-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1314606, encodeId=4365131460641, content=<a href='/topic/show?id=9d4b5554131' target=_blank style='color:#2F92EE;'>#抗癌药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55541, encryptionId=9d4b5554131, topicName=抗癌药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Jun 25 06:26:00 CST 2014, time=2014-06-25, status=1, ipAttribution=)]
    2014-06-25 sunylz

相关资讯

Nat Neurosci:治疗多发性硬化药物fingolimod可加剧记忆消退

记忆消退,顾名思义是指过去回忆的渐渐消失。《自然-神经科学》上的一项研究称,小鼠的记忆消退可在一种目前用于治疗多发性硬化的缓解复发的药物的作用下得到加强。这项发现意味着一旦从人体实验上得出相同的结果,那么这种药物可用来治疗创伤后应激障碍和其他焦虑症。 这种名为fingolimod的药物由一种小分子组成,该小分子可以被控制在惰性状态,并可在体内通过鞘氨醇激酶获得激活。一旦激活,该药物能帮助抑制免疫

“纯意念控制”人工神经康复机器人问世

还记得巴西世界杯开幕式上,患有截瘫的巴西青年诺平托在脑控机械外骨骼技术的帮助下,为世界杯开球的神奇一幕吗?如今,这一幕在天津再次上演。14日,在天津大学和天津市人民医院举办的“纯意念控制人工神经康复机器人系统”发布会上,因中风导致偏瘫的董阿姨通过“想”,“指挥”自己原本无法动作的肢体“听话”地完成相应动作。 该技术历时10年,是国家“863计划”“十二五”国家科技支撑计划和国家优秀青年科学基金

JAMA Neurol:ADCS-PACC——首次用于诊断AD临床前期的功能量表

许多研究提示,在AD的临床前期进行干预可取得较好的效果,因此,临床上迫切需要有新的、灵敏度高的测量工具,用以评估AD临床前期的症状改变。临床前AD认知负荷量表(ADCS-PACC)是世界上首个临床前AD临床试验(A4研究)所应用的主要测量工具,能够评估情景记忆、限时执行功能以及整体认知功能。基于先前数个临床试验所获得的数据,加州大学圣地亚哥Donohue教授等探索了ADCS-PACC用于评估临床前

一个基因变异打乱心脏病新药研发节奏

据世界卫生组织称,因心脏病和中风而死亡的人数要远远高于其他原因导致的死亡人数,这两种疾病每年会夺去1,400万条生命。而它们基本上都围绕着一个“管道”问题:胆固醇颗粒在血管内部堆积,不断刺激血管,直到其中某一处形成阻止血液流向心脏或大脑的恶性凝块。但目前还不清楚有害的蛋白质、脂肪和胆固醇的何种结合方式导致了这些致命的疾病爆发。 现在科学家们已经找到了一条线索:身体中存在一种用以合成甘油三

儿童神经系统恶性肿瘤成儿童第二大“杀手”

天津医科大学附属肿瘤医院脑系肿瘤科主任李文良教授16日表示,近年来,儿童神经系统恶性肿瘤现在整个儿童恶性肿瘤中已升至第二位,发病率颇高,其中胶质瘤、颅咽管瘤、髓母细胞瘤等几种是儿童较为多发的肿瘤。 当日,天津市神经肿瘤专题研讨会新闻发布会在天津肿瘤医院举行。作为此次研讨会的主要负责人,李文良接受记者采访时称,随着外界环境的变化、饮食结构的改变及人们精神压力的增大等因素,神经系统肿瘤也和其

PNAS:大脑如何记住近期的事情?

这项研究为治疗一些神经系统疾病,如阿尔茨海默症和癫痫提出了新观点。日前,来自加州大学圣地亚哥分校,亚利桑那州巴罗神经科学研究所等处的研究人员报道称,人类大脑能将情景记忆“锁”在海马区,将每次回忆提交个单个细胞中的不同分散区域,这确证了神经计算理论学家们长期质疑的问题。 这一研究成果公布在 6 月 16 日的《美国国家科学院院刊》(PNAS)杂志在线版上,这将有助于解析人类记忆的神经基础,并最终有可