Obstet Gynecol:分娩住院期间并发先兆子痫孕妇使用抗高血压药物治疗分析!

2018-02-09 xing.T MedSci原创

由此可见,使用多种抗高血压药物治疗先兆子痫的比例在轻度、中度和严重先兆子痫患者中有所增加。使用抗高血压药物不同医院差异很大,这一趋势与母亲卒中风险降低有关。

近日,妇产科权威杂志Obstetrics and Gynecology上发表了一研究文章,研究人员旨在评估分娩住院期间并发先兆子痫和同期产妇卒中风险的孕妇抗高血压药物使用的时间趋势。

研究人员使用前瞻性数据库进行回顾性队列研究,以评估从2006年到2015年第一季度分娩住院期间并发先兆子痫的孕妇抗高血压药物情况。评估的药物包括硝苯地平、肼苯哒嗪以及口服和静脉注射拉贝洛尔。研究人员根据人口统计学指标和医院因素调整了接受抗高血压药物的模型,并分析了严重先兆子痫妇女住院期间抗高血压药物治疗率,以及评估了分娩住院期间发生卒中的风险。

该研究共纳入239454例先兆子痫患者,其中轻度126595例,中等程度31628例,重度患者81231例。总体而言,105409名妇女接受了高血压药物。从2006年到2014年,所有先兆子痫患者,口服拉贝洛尔的比例从20.3%增加到31.4%,静脉注射拉贝洛尔从13.3%增加到21.4%,肼苯哒嗪从12.8%增加到16.9%,硝苯地平从15.0%增加到18.2%,超过一种药物从16.5%增加到25.8%。接受抗高血压药物治疗的先兆子痫患者比例从2006年的37.8%上升到2015年的49.4%。在调整后的模型中,时间趋势保持显著性。严重先兆子痫患者抗高血压药治疗率因不同医院而有所差异。对于严重的先兆子痫,卒中风险从2006-2008年期间的每10000次分娩中的13.5次(27例)下降到2009-2011年期间的9.7次(25例),到2012-2014年期间为6.0次(20例)(P=0.02)。

由此可见,使用多种抗高血压药物治疗先兆子痫的比例在轻度、中度和严重先兆子痫患者中有所增加。使用抗高血压药物不同医院差异很大,这一趋势与母亲卒中风险降低有关。

原始出处:


Cleary, Kirsten L, et al. Use of Antihypertensive Medications During Delivery Hospitalizations Complicated by Preeclampsia.Obstetrics & Gynecology.2018. https://journals.lww.com/greenjournal/Abstract/publishahead/Use_of_Antihypertensive_Medications_During.98145.aspx

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    2019-01-04 yhy100200
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    2018-07-07 丁鹏鹏
  6. [GetPortalCommentsPageByObjectIdResponse(id=2027112, encodeId=8369202e112c3, content=<a href='/topic/show?id=5dd1558503e' target=_blank style='color:#2F92EE;'>#抗高血压药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55850, encryptionId=5dd1558503e, topicName=抗高血压药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=362b271, createdName=zexyw01, createdTime=Mon Mar 05 22:15:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2044044, encodeId=50be20440447b, content=<a href='/topic/show?id=8513126129d' target=_blank style='color:#2F92EE;'>#NEC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12612, encryptionId=8513126129d, topicName=NEC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Thu Aug 30 11:15:00 CST 2018, time=2018-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2039782, encodeId=85542039e8209, content=<a href='/topic/show?id=bf0f5584ef6' target=_blank style='color:#2F92EE;'>#抗高血压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55847, encryptionId=bf0f5584ef6, topicName=抗高血压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e87531, createdName=klivis, createdTime=Mon Mar 12 05:15:00 CST 2018, time=2018-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2011373, encodeId=5f5020113e3c8, content=<a href='/topic/show?id=840d1e300e5' target=_blank style='color:#2F92EE;'>#TET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17300, encryptionId=840d1e300e5, topicName=TET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cc52251, createdName=yhy100200, createdTime=Fri Jan 04 12:15:00 CST 2019, time=2019-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1757942, encodeId=ec701e579429c, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27e37327108, createdName=丁鹏鹏, createdTime=Sat Jul 07 22:15:00 CST 2018, time=2018-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1275136, encodeId=0af112e51368a, content=<a href='/topic/show?id=263031541b4' target=_blank style='color:#2F92EE;'>#分娩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31541, encryptionId=263031541b4, topicName=分娩)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d590125, createdName=linlin2312, createdTime=Sun Feb 11 07:15:00 CST 2018, time=2018-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1545680, encodeId=597115456805e, content=<a href='/topic/show?id=a383558515b' target=_blank style='color:#2F92EE;'>#抗高血压药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55851, encryptionId=a383558515b, topicName=抗高血压药物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e46713811513, createdName=ms9474365431325850, createdTime=Sun Feb 11 07:15:00 CST 2018, time=2018-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286599, encodeId=877a286599e2, content=不确定性太多.需要努力学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Feb 09 21:50:04 CST 2018, time=2018-02-09, status=1, ipAttribution=)]
    2018-02-11 linlin2312
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  8. [GetPortalCommentsPageByObjectIdResponse(id=2027112, encodeId=8369202e112c3, content=<a href='/topic/show?id=5dd1558503e' target=_blank style='color:#2F92EE;'>#抗高血压药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55850, encryptionId=5dd1558503e, topicName=抗高血压药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=362b271, createdName=zexyw01, createdTime=Mon Mar 05 22:15:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2044044, encodeId=50be20440447b, content=<a href='/topic/show?id=8513126129d' target=_blank style='color:#2F92EE;'>#NEC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12612, encryptionId=8513126129d, topicName=NEC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Thu Aug 30 11:15:00 CST 2018, time=2018-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2039782, encodeId=85542039e8209, content=<a href='/topic/show?id=bf0f5584ef6' target=_blank style='color:#2F92EE;'>#抗高血压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55847, encryptionId=bf0f5584ef6, topicName=抗高血压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e87531, createdName=klivis, createdTime=Mon Mar 12 05:15:00 CST 2018, time=2018-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2011373, encodeId=5f5020113e3c8, content=<a href='/topic/show?id=840d1e300e5' target=_blank style='color:#2F92EE;'>#TET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17300, encryptionId=840d1e300e5, topicName=TET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cc52251, createdName=yhy100200, createdTime=Fri Jan 04 12:15:00 CST 2019, time=2019-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1757942, encodeId=ec701e579429c, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27e37327108, createdName=丁鹏鹏, createdTime=Sat Jul 07 22:15:00 CST 2018, time=2018-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1275136, encodeId=0af112e51368a, content=<a href='/topic/show?id=263031541b4' target=_blank style='color:#2F92EE;'>#分娩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31541, encryptionId=263031541b4, topicName=分娩)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d590125, createdName=linlin2312, createdTime=Sun Feb 11 07:15:00 CST 2018, time=2018-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1545680, encodeId=597115456805e, content=<a href='/topic/show?id=a383558515b' target=_blank style='color:#2F92EE;'>#抗高血压药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55851, encryptionId=a383558515b, topicName=抗高血压药物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e46713811513, createdName=ms9474365431325850, createdTime=Sun Feb 11 07:15:00 CST 2018, time=2018-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286599, encodeId=877a286599e2, content=不确定性太多.需要努力学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Feb 09 21:50:04 CST 2018, time=2018-02-09, status=1, ipAttribution=)]
    2018-02-09 虈亣靌

    不确定性太多.需要努力学习

    0

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