PLoS One：lncRNA或参与了胃癌的发生

2017-09-29 MedSci MedSci原创

越来越多的证据强调了长链非编码RNAs（lncRNAs）在众多生物过程中的重要作用。然而，在胃癌中lncRNAs的基因组表达谱和其潜在的生物学功能尚未可知。研究人员从TCGA中获得420例胃癌患者的RNA测序数据，确定了胃癌与癌旁正常组织相比的1294个差异表达的lncRNA。此外，研究人员还发现了肠型和弥漫型胃癌247个差异表达的lncRNA。生存分析显示，33个lncRNA与患者总生存率独立相

越来越多的证据强调了长链非编码RNAs（lncRNAs）在众多生物过程中的重要作用。然而，在胃癌中lncRNAs的基因组表达谱和其潜在的生物学功能尚未可知。

研究人员从TCGA中获得420例胃癌患者的RNA测序数据，确定了胃癌与癌旁正常组织相比的1294个差异表达的lncRNA。此外，研究人员还发现了肠型和弥漫型胃癌247个差异表达的lncRNA。生存分析显示，33个lncRNA与患者总生存率独立相关，其中其中6lncRNA进行了验证。位于SCNAs区域的181个差异表达的lncRNA及拷贝数与RNA表达水平之间的关系进行了分析。此外，研究人员通过构建mRNAs 和 lncRNAs的共表达网络推测lncRNA的功能。

总之，该研究表明lncRNA参与了胃癌的发生，并进行了初步分析，为进一步探究lncRNA在胃癌发生中的功能提供研究基础。

原始出处：

Weiwei Han, Zhenyu Zhang, et al. Integrated analysis of long non-coding RNAs in human gastric cancer: An in silico study. PLoS One. 2017; 12(8): e0183517. Published online 2017 Aug 25. doi: 10.1371/journal.pone.0183517.

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2018-02-21 119337457

#Plos one#

23 0
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2018-03-07 yanjie6253_56072842

#CRN#

28 0
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2017-10-06 thlabcde

好资料学习了!

64 0
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2017-10-01 xzw113

#lncRNA#

33 0
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2017-09-29 lietome15

好文.值得点赞!认真学习了.把经验应用于实践.为患者解除病痛.

68 0
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2017-09-29 天涯183

非常好的文章.学习了

57 0
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2017-09-29 欣怡b88dc255

这项研究烧钱不少吧

61 0
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2017-09-29 changjiu

学习了.谢谢

66 0

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