JACC:左心耳封堵术对患者神经内分泌系统有明显影响!

2018-01-12 MedSci MedSci原创

左心耳封堵(包括心外膜封堵装置和心内膜封堵装置)对患者全身稳态的影响尚属未知。本研究的目的旨在评估左心耳封堵对患者神经体液的影响,主要是对肾素-血管紧张素-醛固酮系统与自主神经系统的影响。本前瞻性单中心观察性研究纳入了77名行左心耳封堵术(包括38名心外膜和39名心内膜封堵装置)的患者,并对所有患者术前、术后即刻、术后24h和术后3个月的关键激素水平包括肾上腺素能系统、肾素血管紧张素醛固酮系统、代

左心耳封堵(包括心外膜封堵装置和心内膜封堵装置)对患者全身稳态的影响尚属未知。本研究的目的旨在评估左心耳封堵对患者神经体液的影响,主要是对肾素-血管紧张素-醛固酮系统与自主神经系统的影响。本前瞻性单中心观察性研究纳入了77名行左心耳封堵术(包括38名心外膜和39名心内膜封堵装置)的患者,并对所有患者术前、术后即刻、术后24h和术后3个月的关键激素水平包括肾上腺素能系统、肾素血管紧张素醛固酮系统、代谢系统(脂联素、胰岛素、游离脂肪酸、β-羟基丁酸酯和甘油)和尿钠排泄进行了检测。在心内膜装置组,与基线水平相比,患者术后24h和3个月的肾上腺素、去甲肾上腺素和醛固酮水平明显降低(p < 0.05),但在术后即刻没有明显差异。在心外膜装置组,患者术后3个月的脂联素和胰岛素水平明显升高,而游离脂肪酸明显降低,N-末端A型钠尿肽和B型钠尿肽在心外膜装置植入后即刻有明显降低,但术后3个月即恢复正常水平。此外,收缩压在心外膜装置植入后有所下降,而在心内膜装置植入后无明显差异。研究结果显示,在左心耳封堵后(包括心内膜和心外膜装置),患者的血流动力学和神经内分泌均有较明显的变化。原始出处:Dhanu

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    2018-03-27 gwc392
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    2018-06-11 ycmayy
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    2018-12-10 hbwxf
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    2018-01-14 jxrzshh
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    2018-01-12 Y—xianghai

    学习了新知识

    0

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