Semin Arthritis Rheu:女性类风湿性关节炎和COPD、哮喘的发病风险

2018-04-30 xiangting MedSci原创

在这项前瞻性队列研究中,RA与偶发性COPD风险升高相关,与生活方式混杂因素和包括吸烟在内的诊断后介质无关。

这项研究探讨了RA是否会增加慢性阻塞性肺病(COPD)或哮喘的发病风险,与RA发病前或包括吸烟在内的诊断后介导这些呼吸道疾病的因素无关。研究人员在前瞻性护士健康研究中(n = 121,701例女性; 1976-2014),确定了一个偶发性RA患者队列。并根据年龄和RA诊断年份,将1例RA女性患者与10例无RA患者进行匹配,排除基线时患COPD或哮喘的女性。通过两年一次的问卷和病历获得数据。通过逆概率加权校正混杂因子和时变介质,使用边缘结构模型来确定RA对COPD或哮喘的独立影响, 共确定了843例RA女性患者,与8,399例无RA对照进行匹配。平均年龄为59.8岁,平均随访时间为RA女性患者18.6年(SD = 9.0),对照为18.8年(SD = 9.5)。在RA女性患者中发现68例(8.1%)偶发性COPD患者和40例(4.7%)哮喘患者,对照者中发现459例(5.5%)COPD患者和268例(3.2%)哮喘患者。校正年龄和指数日期年份的匹配因素后,与对照相比,RA与COPD(HR = 1.52,95%CI:1.17-1.97)和哮喘(HR = 1.55,95%CI:1.

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    2018-05-02 lmm397
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    2018-05-02 zhaojie88
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    2018-05-01 13718711b3m

    学习了.获益匪浅.感谢分享

    0

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