J Investig Clin Dent:刮治和根面平整对慢性牙周炎吸烟者龈沟液细胞因子/趋化因子水平的影响

2018-03-03 MedSci MedSci原创

在本研究中,评估了刮治和根部平整(SRP)对慢性牙周炎吸烟者龈沟液(GCF)细胞因子/趋化因子水平的影响。PICO(人口,干预,比较,结果)问题是:在慢性牙周炎(人群)的吸烟者中,SRP(干预)与非慢性牙周炎非吸烟者相比,GCF细胞因子/趋化因子水平(结果)的差异。研究人员检索了2017年9月之前相关的文献。在4330个标题中,9个研究报告了13种不同细胞因子/趋化因子的水平。8项研究偏倚风险中等

在本研究中,评估了刮治和根部平整(SRP)对慢性牙周炎吸烟者龈沟液(GCF)细胞因子/趋化因子水平的影响。PICO(人口,干预,比较,结果)问题是:在慢性牙周炎(人群)的吸烟者中,SRP(干预)与非慢性牙周炎非吸烟者相比,GCF细胞因子/趋化因子水平(结果)的差异。

研究人员检索了2017年9月之前相关的文献。在4330个标题中,9个研究报告了13种不同细胞因子/趋化因子的水平。8项研究偏倚风险中等,而1项研究偏倚风险高。几乎所有细胞因子/趋化因子都是促炎细胞因子。吸烟-慢性牙周炎组SRP后,4项临床研究中研究的5种细胞因子/趋化因子减少。1项研究观察到随访时,白细胞介素-17的GCF水平增加,而SCP和非吸烟者慢性牙周炎组的抗炎骨保护素均降低。然而,SCP组中大部分细胞因子/趋化因子在随访时并未发生变化。

该研究结果表明,目前的研究证据不足以证明SRP对慢性牙周炎吸烟者GCF细胞因子/趋化因子存在影响。未来需要研究与胶原降解和牙槽骨破坏有关的促炎细胞因子/趋化因子的变化。

原始出处:

Eshghipour B, Tofighi H, et al., Effect of scaling and root planing on gingival crevicular fluid cytokine/chemokine levels in smokers with chronic periodontitis: A systematic review.J Investig Clin Dent. 2018 Feb 15. doi: 10.1111/jicd.12327. [Epub ahead of print]

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