Chest:可视化估计的冠状动脉钙化可预测COPD患者心血管疾病!

2018-06-12 xing.T MedSci原创

由此可见,CAC的简单视觉评分在预测患有COPD和不患有COPD的吸烟者CAD事件具有很好的效果。

COPD与心血管疾病(CVD)相关,并且为冠状动脉钙化(CAC)提供了更多的预后信息。随着非门控CT扫描在临床实践中的应用越来越多,近日,呼吸领域权威杂志chest上发表了一篇研究文章,研究人员假设视觉韦斯顿CAC评分将如AGAST评分一样可以预测COPD患者冠状动脉事件和冠状动脉病变(CAD)的患病情况和发生率。

研究人员对1875名纳入COPD基因研究的当前和既往吸烟者基于CT扫描测定Agatston评分和Weston评分。研究人员记录了基线心血管疾病和纵向随访心脏事件的发生率,并使用受试者操作特性分析测量CAC分数的准确性,以及使用Cox比例风险分析来估计发生心脏事件的风险。

在基线时发现133例(7.1%)CAD患者。分别有413例(22%)和241例(12.9%)显著的Weston(>7)和Agatston(>400)评分确定的CAC,两种方法具有显著相关性(r=0.84;P<0.001)。超过5年的随访期间,127例(6.8%)患者发生CVD事件。对于预测CAD的患病情况,Weston和Agatston的c指数分别为0.78和0.74,预测CVD的发生率分别为0.62和0.61。调整年龄、种族、性别、吸烟包年、FEV1、肺气肿百分比和CT扫描仪类型后,Weston>7与首次急性冠状动脉事件的发生时间相关(HR=2.16,95%CI为1.32-3.53;P=0.002),而Agtston>400则不是(HR=1.75,95%CI为0.99-3.09;P=0.053)。

由此可见,CAC的简单视觉评分在预测患有COPD和不患有COPD的吸烟者CAD事件具有很好的效果。

原始出处:

Surya P. Bhatt,et al. Visual estimate of coronary artery calcium predicts cardiovascular disease in COPD.chest.2018.https://doi.org/10.1016/j.chest.2018.05.037

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    2018-06-15 Smile2680
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createdBy=ccb99370406, createdName=andy2090, createdTime=Wed Jun 13 22:50:00 CST 2018, time=2018-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323526, encodeId=176132352655, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Tue Jun 12 09:59:45 CST 2018, time=2018-06-12, status=1, ipAttribution=)]
    2018-06-26 医生无国界

    这个要好好研究.可以再搞一个好课题

    0

  6. 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  8. 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    2018-06-13 gous
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    2018-06-12 龙胆草

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